2019
Safety, pharmacokinetics, and pharmacodynamic activity of obinutuzumab, a type 2 anti-CD20 monoclonal antibody for the desensitization of candidates for renal transplant
Redfield RR, Jordan SC, Busque S, Vincenti F, Woodle ES, Desai N, Reed EF, Tremblay S, Zachary AA, Vo AA, Formica R, Schindler T, Tran H, Looney C, Jamois C, Green C, Morimoto A, Rajwanshi R, Schroeder A, Cascino MD, Brunetta P, Borie D. Safety, pharmacokinetics, and pharmacodynamic activity of obinutuzumab, a type 2 anti-CD20 monoclonal antibody for the desensitization of candidates for renal transplant. American Journal Of Transplantation 2019, 19: 3035-3045. PMID: 31257724, PMCID: PMC6899639, DOI: 10.1111/ajt.15514.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntibodies, Monoclonal, HumanizedAntigens, CD20Antineoplastic Agents, ImmunologicalCohort StudiesDesensitization, ImmunologicFemaleFollow-Up StudiesGraft SurvivalHLA AntigensHumansKidney Failure, ChronicKidney TransplantationMaleMaximum Tolerated DoseMiddle AgedPatient SelectionPrognosisRisk FactorsTissue DistributionYoung AdultConceptsB-cell depletionSerious adverse eventsIntravenous immunoglobulinCell depletionAdverse eventsOpen-label phase 1b studyType 2Doses of IVIGIncomplete B cell depletionPanel reactive antibody scorePeripheral B-cell depletionEnd-stage renal diseasePhase 1b studyAnti-HLA antibodiesRetroperitoneal lymph nodesSingle antigen beadsTime of transplantCD20 monoclonal antibodyMedian followRenal transplantKidney transplantMost patientsWeek 24Lymph nodesRenal disease
2017
Perspectives on the Strengths and Weaknesses of the National Kidney Allocation System
Formica RN. Perspectives on the Strengths and Weaknesses of the National Kidney Allocation System. Clinical Journal Of The American Society Of Nephrology 2017, 12: 2056-2056. PMID: 29162591, PMCID: PMC5718280, DOI: 10.2215/cjn.08640817.Peer-Reviewed Original Research
2016
Simultaneous liver kidney transplantation
Formica RN. Simultaneous liver kidney transplantation. Current Opinion In Nephrology & Hypertension 2016, 25: 577-582. PMID: 27653420, DOI: 10.1097/mnh.0000000000000260.Peer-Reviewed Original ResearchConceptsSimultaneous liver-kidney transplantationKidney allocation systemKidney Donor Profile IndexLiver-kidney transplantationSLK recipientsKidney transplantationMayo End-Stage Liver Disease (MELD) scoreEnd-stage liver disease (MELD) scoreNew kidney allocation systemLiver disease patientsLiver Disease scoreMedical Eligibility CriteriaLiver allocation policyAllocation of kidneysProfile indexDisease patientsDisease scoreEligibility criteriaOrgan allocationKidneyTransplantationSignificant increaseGranular assessmentSignificant proportionLiver