2021
Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease
Lu Y, Toyonaga T, Naganawa M, Gallezot JD, Chen MK, Mecca AP, van Dyck CH, Carson RE. Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease. NeuroImage 2021, 238: 118248. PMID: 34119639, PMCID: PMC8454285, DOI: 10.1016/j.neuroimage.2021.118248.Peer-Reviewed Original Research
2020
Quantitative Cerebral Blood Flow with PET in the 1980s: Going with the Flow.
Carson RE. Quantitative Cerebral Blood Flow with PET in the 1980s: Going with the Flow. Journal Of Nuclear Medicine 2020, 61: 89s-90s. PMID: 33293455, DOI: 10.2967/jnumed.120.252130.Peer-Reviewed Original ResearchCerebrovascular CirculationHistory, 20th CenturyHistory, 21st CenturyHumansPositron-Emission TomographyBinding of the synaptic vesicle radiotracer [11C]UCB-J is unchanged during functional brain activation using a visual stimulation task
Smart K, Liu H, Matuskey D, Chen MK, Torres K, Nabulsi N, Labaree D, Ropchan J, Hillmer AT, Huang Y, Carson RE. Binding of the synaptic vesicle radiotracer [11C]UCB-J is unchanged during functional brain activation using a visual stimulation task. Cerebrovascular And Brain Metabolism Reviews 2020, 41: 1067-1079. PMID: 32757741, PMCID: PMC8054713, DOI: 10.1177/0271678x20946198.Peer-Reviewed Original ResearchConceptsVisual cortexVisual stimulationPositron emission tomography radioligandBrain activationBlood flow increasesVolume of distributionPrimary visual cortexCheckerboard visual stimulationFunctional brain activationFunctional magnetic resonanceReference tissue modelFMRI BOLD responsesSynaptic densityVisual stimulation taskOne-tissue compartment modelHealthy volunteersNeuronal firingTomography radioligandPET scansTissue influxVivo measuresRobust increaseBOLD responseTracer influxStimulation task
2000
The Suitability of [11C]-α-Methyl-L-tryptophan as a Tracer for Serotonin Synthesis: Studies With Dual Administration of [11C] and [14C] Labeled Tracer
Shoaf S, Carson R, Hommer D, Williams W, Higley J, Schmall B, Herscovitch P, Eckelman W, Linnoila M. The Suitability of [11C]-α-Methyl-L-tryptophan as a Tracer for Serotonin Synthesis: Studies With Dual Administration of [11C] and [14C] Labeled Tracer. Cerebrovascular And Brain Metabolism Reviews 2000, 20: 244-252. PMID: 10698060, DOI: 10.1097/00004647-200002000-00004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain ChemistryCarbon RadioisotopesCerebrovascular CirculationHydroxyindoleacetic AcidMacaca mulattaMaleSerotoninTomography, Emission-ComputedTryptophanConceptsPositron emission tomographySerotonin synthesisOverdose of phenobarbitalBrain serotonin synthesis rateIsoflurane-anesthetized rhesus monkeysSerotonin synthesis rateBrain concentrationsSecond doseBrain samplesEmission tomographyRhesus monkeysDual administrationTryptophan uptakePatlak plotSerotoninMinimal conversionAdministrationMonkeysSynthesis rateL-tryptophanPET imagesPET dataTotal countOverdoseExternal quantification
1999
Bolus Injection Versus Slow Infusion of [15O]Water for Positron Emission Tomography Activation Studies
Beason-Held L, Desmond R, Herscovitch P, Carson R. Bolus Injection Versus Slow Infusion of [15O]Water for Positron Emission Tomography Activation Studies. Cerebrovascular And Brain Metabolism Reviews 1999, 19: 843-852. PMID: 10458591, DOI: 10.1097/00004647-199908000-00003.Peer-Reviewed Original ResearchAdultBrainBrain MappingCerebrovascular CirculationFaceFemaleHumansImage Processing, Computer-AssistedInfusions, IntravenousInjections, IntravenousMemory, Short-TermModels, CardiovascularModels, NeurologicalOxygen RadioisotopesPattern Recognition, VisualReference ValuesRegional Blood FlowSensitivity and SpecificityTomography, Emission-ComputedWater
1997
Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study.
Braun AR, Balkin TJ, Wesenten NJ, Carson RE, Varga M, Baldwin P, Selbie S, Belenky G, Herscovitch P. Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study. Brain 1997, 120: 1173-1197. PMID: 9236630, DOI: 10.1093/brain/120.7.1173.Peer-Reviewed Original ResearchConceptsSlow-wave sleepSleep-wake cycleHeteromodal association areasREM sleepBasal gangliaSensory cortexState-dependent changesAssociation cortexAssociation areasRegional cerebral blood flowRapid eye movement (REM) sleepActivity of limbicMesial temporal cortexCerebral blood flowEye movement sleepSecondary sensory cortexNormal male volunteersCharacteristics of sleepHeteromodal association cortexFrontoparietal association cortexUnimodal sensory areasREM sleep stateStages of sleepStatistical parametric mappingCentrencephalic structures
1992
PET imaging of opiate receptor binding in human epilepsy using [18F]cyclofoxy
Theodore W, Carson R, Andreasen P, Zametkin A, Blasberg R, Leiderman D, Rice K, Newman A, Channing M, Dunn B, Simpson N, Herscovitch P. PET imaging of opiate receptor binding in human epilepsy using [18F]cyclofoxy. Epilepsy Research 1992, 13: 129-139. PMID: 1334456, DOI: 10.1016/0920-1211(92)90068-5.Peer-Reviewed Original ResearchConceptsComplex partial seizuresEEG fociBasal gangliaTemporal lobeBrain regionsPotent opiate antagonistMesial temporal lobeCerebral blood flowOpiate receptor bindingEEG-video monitoringLateral temporal cortexLow specific bindingSpecific bindingPartial seizuresTime-activity dataKappa receptorsOpiate antagonistEpileptic focusHuman epilepsyFrontal cortexIndividual patientsOccipital lobeMean VTBlood flowBlood samples
1991
Precision and Accuracy Considerations of Physiological Quantitation in PET
Carson R. Precision and Accuracy Considerations of Physiological Quantitation in PET. Cerebrovascular And Brain Metabolism Reviews 1991, 11: a45-a50. PMID: 1997487, DOI: 10.1038/jcbfm.1991.36.Peer-Reviewed Original ResearchBrainCerebrovascular CirculationGlucoseHumansMathematicsModels, BiologicalTomography, Emission-ComputedDissociation of object and spatial visual processing pathways in human extrastriate cortex.
Haxby JV, Grady CL, Horwitz B, Ungerleider LG, Mishkin M, Carson RE, Herscovitch P, Schapiro MB, Rapoport SI. Dissociation of object and spatial visual processing pathways in human extrastriate cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 1621-1625. PMID: 2000370, PMCID: PMC51076, DOI: 10.1073/pnas.88.5.1621.Peer-Reviewed Original ResearchConceptsExtrastriate cortexRegional cerebral blood flowDissociation of ObjectPrimate extrastriate cortexCerebral blood flowHealthy young menExtrastriate visual pathwaysHuman extrastriate cortexPositron emission tomographyAnterior temporal cortexSuperior parietal cortexLateral occipital cortexNew cortical areasSensorimotor control taskVisual extrastriate cortexBolus injectionOccipital cortexBlood flowCortical areasTemporal cortexNeuroanatomical locationVisual pathwayParietal cortexVisual processing pathwayEmission tomography
1986
Weighted Integration Method for Local Cerebral Blood Flow Measurements with Positron Emission Tomography
Carson R, Huang S, Green M. Weighted Integration Method for Local Cerebral Blood Flow Measurements with Positron Emission Tomography. Cerebrovascular And Brain Metabolism Reviews 1986, 6: 245-258. PMID: 3485644, DOI: 10.1038/jcbfm.1986.38.Peer-Reviewed Original ResearchBrainCerebrovascular CirculationDiagnostic ErrorsHumansMathematicsModels, TheoreticalTomography, Emission-Computed
1983
Quantitative Measurement of Local Cerebral Blood Flow in Humans by Positron Computed Tomography and 15O-Water
Huang S, Carson RE, Hoffman EJ, Carson J, MacDonald N, Barrio JR, Phelps ME. Quantitative Measurement of Local Cerebral Blood Flow in Humans by Positron Computed Tomography and 15O-Water. Cerebrovascular And Brain Metabolism Reviews 1983, 3: 141-153. PMID: 6601663, DOI: 10.1038/jcbfm.1983.21.Peer-Reviewed Original ResearchMeSH KeywordsAdultBloodBody WaterBrain ChemistryCerebrovascular CirculationHumansMethodsOxygen RadioisotopesTime FactorsTomography, Emission-ComputedWater
1982
Measurement of Local Blood Flow and Distribution Volume with Short-Lived Isotopes: A General Input Technique
Huang S, Carson R, Phelps M. Measurement of Local Blood Flow and Distribution Volume with Short-Lived Isotopes: A General Input Technique. Cerebrovascular And Brain Metabolism Reviews 1982, 2: 99-108. PMID: 6977546, DOI: 10.1038/jcbfm.1982.11.Peer-Reviewed Original Research