2021
PET Imaging Estimates of Regional Acetylcholine Concentration Variation in Living Human Brain
Smart K, Naganawa M, Baldassarri SR, Nabulsi N, Ropchan J, Najafzadeh S, Gao H, Navarro A, Barth V, Esterlis I, Cosgrove KP, Huang Y, Carson RE, Hillmer AT. PET Imaging Estimates of Regional Acetylcholine Concentration Variation in Living Human Brain. Cerebral Cortex 2021, 31: 2787-2798. PMID: 33442731, PMCID: PMC8355478, DOI: 10.1093/cercor/bhaa387.Peer-Reviewed Original ResearchConceptsACh concentrationHuman volunteersHigh ACh concentrationsMuscarinic antagonist scopolamineHealthy human volunteersHuman brainCholinergic receptorsNicotine challengeAntagonist scopolaminePreclinical studiesStriatal regionsPET scansEndogenous neurotransmittersNeuropsychiatric diseasesNonhuman primatesWhole-brain imagesDrug occupancyNicotinic ligandsClinical populationsBrainAcetylcholineDistinct functional rolesStriatumVolunteersFunctional role
2011
P4‐253: Receptor occupancy of the 5‐HT6 receptor antagonist SAM‐760 in non‐human primates and healthy human volunteers
Comery T, Zasadny K, Morris E, Antinew J, Bell J, Billing B, Boyden T, Esterlis I, Huang Y, Kupiec J, Kuszpit K, Leil T, Nabulsi N, Planeta‐Wilson B, Plotka A, Skaddan M, Vandal G, Carson R, Katz E, McCarthy T. P4‐253: Receptor occupancy of the 5‐HT6 receptor antagonist SAM‐760 in non‐human primates and healthy human volunteers. Alzheimer's & Dementia 2011, 7: s794-s795. DOI: 10.1016/j.jalz.2011.05.2278.Peer-Reviewed Original ResearchP3‐431: Translational receptor occupancy for the 5‐HT4 partial agonist PF‐04995274 in rats, non‐human primates and healthy volunteers
Grimwood S, Drummond E, Zasadny K, Skaddan M, Brodney M, Coffman K, Nicholas T, Duvvuri S, Raunig D, Leurent C, Rowinski C, Park Y, Ogden A, Sawant A, Miller E, Rapp T, Wang Y, Planeta‐Wilson B, Ropchan J, Carson R, Morris E, Ding Y, Katz E. P3‐431: Translational receptor occupancy for the 5‐HT4 partial agonist PF‐04995274 in rats, non‐human primates and healthy volunteers. Alzheimer's & Dementia 2011, 7: s653-s653. DOI: 10.1016/j.jalz.2011.05.1875.Peer-Reviewed Original Research