2019
In vivo imaging of D2 receptors and corticosteroids predict behavioural responses to captivity stress in a wild bird
Lattin CR, Merullo DP, Riters LV, Carson RE. In vivo imaging of D2 receptors and corticosteroids predict behavioural responses to captivity stress in a wild bird. Scientific Reports 2019, 9: 10407. PMID: 31320692, PMCID: PMC6639298, DOI: 10.1038/s41598-019-46845-x.Peer-Reviewed Original ResearchConceptsWild houseMore time feedingWild birdsReceptor bindingIndividual variationBirdsUnderstanding of linksCaptivityPhysiological mechanismsLong-term stressorsTime feedingStress resilienceCaptivity stressPhysiological variationsNeuroendocrine phenotypeBindingPhysiologyBehavioral responsesSubset of individualsStressorsWildlifePhenotypeImportant implicationsIndividual's physiological variationsStress
2016
OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding
Pittenger C, Adams TG, Gallezot JD, Crowley MJ, Nabulsi N, Ropchan J, Gao H, Kichuk SA, Simpson R, Billingslea E, Hannestad J, Bloch M, Mayes L, Bhagwagar Z, Carson RE. OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding. Journal Of Affective Disorders 2016, 196: 87-96. PMID: 26919057, PMCID: PMC4808438, DOI: 10.1016/j.jad.2016.02.021.Peer-Reviewed Original ResearchConceptsPrepulse inhibitionObsessive-compulsive disorderReceptor availabilitySensorimotor gatingOCD patientsImpaired sensorimotor gatingOCD-like behaviorNon-depressed OCD patientsPositron emission tomographyBasal gangliaSerotonergic regulationHealthy controlsSerotonin systemPositive correlationWidespread positive correlationsDiagnostic groupsCortical regionsEmission tomographyOrbitofrontal cortexPatientsReceptor bindingOCD diagnosisSignificant correlationSignificant main effectImportant alterations