2022
CD74 ablation rescues type 2 diabetes mellitus-induced cardiac remodeling and contractile dysfunction through pyroptosis-evoked regulation of ferroptosis
Chen L, Yin Z, Qin X, Zhu X, Chen X, Ding G, Sun D, Wu NN, Fei J, Bi Y, Zhang J, Bucala R, Ren J, Zheng Q. CD74 ablation rescues type 2 diabetes mellitus-induced cardiac remodeling and contractile dysfunction through pyroptosis-evoked regulation of ferroptosis. Pharmacological Research 2022, 176: 106086. PMID: 35033649, DOI: 10.1016/j.phrs.2022.106086.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntigens, Differentiation, B-LymphocyteCell LineDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2FemaleFerroptosisGene ExpressionHistocompatibility Antigens Class IIHumansMacrophage Migration-Inhibitory FactorsMaleMice, KnockoutMiddle AgedMyocardial ContractionMyocardiumNLR Family, Pyrin Domain-Containing 3 ProteinOxidative StressOxygen ConsumptionPyroptosisRatsVentricular RemodelingConceptsHigh glucose/high fatMacrophage migration inhibitory factorCardiac remodelingContractile dysfunctionCell death domainGene Ontology termsInhibitors of MIFRecombinant macrophage migration inhibitory factorCytokine macrophage migration inhibitory factorType 2 diabetes mellitusOntology termsDeath domainLipid peroxidationGlobal metabolic defectsKEGG analysisPlasma MIF levelsInjection of streptozotocinMitochondrial defectsHigh-fat dietMigration inhibitory factorInhibitor of NLRP3Cell deathPrecise interplayMitochondrial dysfunctionCognate receptors
1999
Inhibition of advanced glycation endproduct formation by acetaldehyde: Role in the cardioprotective effect of ethanol
Al-Abed Y, Mitsuhashi T, Li H, Lawson J, FitzGerald G, Founds H, Donnelly T, Cerami A, Ulrich P, Bucala R. Inhibition of advanced glycation endproduct formation by acetaldehyde: Role in the cardioprotective effect of ethanol. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 2385-2390. PMID: 10051651, PMCID: PMC26793, DOI: 10.1073/pnas.96.5.2385.Peer-Reviewed Original Research
1996
Effects of aminoguanidine in preventing experimental diabetic nephropathy are related to the duration of treatment
Soulis T, Cooper M, Vranes D, Bucala R, Jerums G. Effects of aminoguanidine in preventing experimental diabetic nephropathy are related to the duration of treatment. Kidney International 1996, 50: 627-634. PMID: 8840295, DOI: 10.1038/ki.1996.358.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiabetes Mellitus, ExperimentalDiabetic NephropathiesGlycation End Products, AdvancedGuanidinesMaleRatsRats, Sprague-DawleyTime FactorsConceptsRenal advanced glycation end productsAdvanced glycation end productsExperimental diabetic nephropathyDiabetic nephropathyEffect of aminoguanidineDiabetic ratsAminoguanidine treatmentMesangial expansionStudy periodAccumulation of AGEsUrinary albumin excretionTiming of therapyDevelopment of albuminuriaWeeks of treatmentDuration of treatmentGlycation end productsTiming of treatmentPresence of aminoguanidineAminoguanidine administrationAminoguanidine therapyAlbumin excretionRenoprotective effectsTissue fluorescenceExperimental diabetesLate administration
1995
A Role for DNA Mutations in Diabetes-Associated Teratogenesis in Transgenic Embryos
Lee A, Plump A, DeSimone C, Cerami A, Bucala R. A Role for DNA Mutations in Diabetes-Associated Teratogenesis in Transgenic Embryos. Diabetes 1995, 44: 20-24. PMID: 7813809, DOI: 10.2337/diab.44.1.20.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBlood GlucoseCongenital AbnormalitiesDiabetes Mellitus, ExperimentalDNAEmbryo, MammalianEmbryonic and Fetal DevelopmentFemaleHyperglycemiaLac OperonMaleMiceMice, TransgenicMolecular Sequence DataPolymerase Chain ReactionPregnancyPregnancy in DiabeticsConceptsDNA mutationsDiabetic environmentInsulin-dependent diabetic mothersMaternal diabetic environmentTransgenic mouse model systemCause of deathMouse model systemTransgenic embryosEmbryonic developmentTarget genesDiabetic mothersFetal malformationsGestational periodNormoglycemic conditionsCongenital malformationsHyperglycemic environmentDiabetic embryopathyFirst direct evidenceMutation frequencyModel systemGenotoxic effectsDiabetesMutant frequencyMalformationsTwofold increase