2000
Macrophage Migration Inhibitory Factor Release by Macrophages after Ingestion of Plasmodium chabaudi-Infected Erythrocytes: Possible Role in the Pathogenesis of Malarial Anemia
Martiney J, Sherry B, Metz C, Espinoza M, Ferrer A, Calandra T, Broxmeyer H, Bucala R. Macrophage Migration Inhibitory Factor Release by Macrophages after Ingestion of Plasmodium chabaudi-Infected Erythrocytes: Possible Role in the Pathogenesis of Malarial Anemia. Infection And Immunity 2000, 68: 2259-2267. PMID: 10722628, PMCID: PMC97412, DOI: 10.1128/iai.68.4.2259-2267.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnemiaAnimalsBone MarrowCells, CulturedDose-Response Relationship, DrugEnzyme-Linked Immunosorbent AssayErythrocytesErythroid Precursor CellsErythropoiesisErythropoietinFemaleImmunohistochemistryLeukopoiesisLiverMacrophage Migration-Inhibitory FactorsMacrophagesMalariaMiceMice, Inbred BALB CMice, Inbred C3HPlasmodium chabaudiSpleenTime FactorsConceptsMacrophage migration inhibitory factorChabaudi-infected erythrocytesMalarial anemiaP. chabaudi-infected miceBALB/c miceP. chabaudi-infected erythrocytesTumor necrosis factor alphaMacrophage migration inhibitory factor releaseHuman falciparum malariaRed blood cell destructionPlasmodium falciparum infectionMigration inhibitory factorNecrosis factor alphaSuppression of erythropoiesisAntibody neutralization studiesBlood cell destructionHost-derived factorsPlasmodium chabaudi-infected erythrocytesErythropoiesis inhibitorMalaria anemiaActive diseaseCerebral malariaChabaudi infectionFalciparum malariaFalciparum infection
1999
Inhibition of advanced glycation endproduct formation by acetaldehyde: Role in the cardioprotective effect of ethanol
Al-Abed Y, Mitsuhashi T, Li H, Lawson J, FitzGerald G, Founds H, Donnelly T, Cerami A, Ulrich P, Bucala R. Inhibition of advanced glycation endproduct formation by acetaldehyde: Role in the cardioprotective effect of ethanol. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 2385-2390. PMID: 10051651, PMCID: PMC26793, DOI: 10.1073/pnas.96.5.2385.Peer-Reviewed Original Research
1997
The Pathogenic Role of Macrophage Migration Inhibitory Factor in Immunologically Induced Kidney Disease in the Rat
Lan H, Bacher M, Yang N, Mu W, Nikolic-Paterson D, Metz C, Meinhardt A, Bucala R, Atkins R. The Pathogenic Role of Macrophage Migration Inhibitory Factor in Immunologically Induced Kidney Disease in the Rat. Journal Of Experimental Medicine 1997, 185: 1455-1466. PMID: 9126926, PMCID: PMC2196273, DOI: 10.1084/jem.185.8.1455.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAntibody FormationCell Adhesion MoleculesGene ExpressionGlomerulonephritisHypersensitivity, DelayedIntercellular Adhesion Molecule-1Interleukin-1Macrophage Migration-Inhibitory FactorsMaleMiceNitric Oxide SynthaseRabbitsRatsRats, Sprague-DawleyRNA, MessengerSkinTime FactorsVascular Cell Adhesion Molecule-1ConceptsMacrophage migration inhibitory factorControl antibody-treated animalsDelayed-type hypersensitivity responseAnti-MIF treatmentAntibody-treated animalsMigration inhibitory factorAdhesion molecule-1Hypersensitivity responseKidney diseaseLeukocytic infiltrationHistological damageCrescentic anti-glomerular basement membrane (GBM) glomerulonephritisMolecule-1Skin delayed-type hypersensitivity responseInducible nitric oxide synthase (iNOS) expressionAnti-glomerular basement membrane glomerulonephritisInhibitory factorVascular cell adhesion molecule-1Nitric oxide synthase expressionIntercellular adhesion molecule-1Cell adhesion molecule-1Rabbit anti-rat GBM serumProgressive renal injuryRenal function impairmentAnti-GBM glomerulonephritis
1996
Effects of aminoguanidine in preventing experimental diabetic nephropathy are related to the duration of treatment
Soulis T, Cooper M, Vranes D, Bucala R, Jerums G. Effects of aminoguanidine in preventing experimental diabetic nephropathy are related to the duration of treatment. Kidney International 1996, 50: 627-634. PMID: 8840295, DOI: 10.1038/ki.1996.358.Peer-Reviewed Original ResearchConceptsRenal advanced glycation end productsAdvanced glycation end productsExperimental diabetic nephropathyDiabetic nephropathyEffect of aminoguanidineDiabetic ratsAminoguanidine treatmentMesangial expansionStudy periodAccumulation of AGEsUrinary albumin excretionTiming of therapyDevelopment of albuminuriaWeeks of treatmentDuration of treatmentGlycation end productsTiming of treatmentPresence of aminoguanidineAminoguanidine administrationAminoguanidine therapyAlbumin excretionRenoprotective effectsTissue fluorescenceExperimental diabetesLate administrationHydroxyalkenal Formation Induced by Advanced Glycosylation of Low Density Lipoprotein (∗)
Al-Abed Y, Bucala R, Liebich H, Voelter W. Hydroxyalkenal Formation Induced by Advanced Glycosylation of Low Density Lipoprotein (∗). Journal Of Biological Chemistry 1996, 271: 2892-2896. PMID: 8621676, DOI: 10.1074/jbc.271.6.2892.Peer-Reviewed Original ResearchConceptsChemical ionization mass spectroscopyGas chromatography-mass spectrometry analysisIonization mass spectroscopyChromatography-mass spectrometry analysisOxidation product 4Acid side chainsUnsaturated fatty acyl groupsTransition metalsFatty acid side chainsHead groupsMass spectroscopySide chainsProduct 4Chemical basisCovalent additionFatty acyl groupsFree radical generating systemOxidationRadical generating systemSpectrometry analysisAcyl groupsMajor compoundsTissue LDL receptorsHigh affinityOxidative modification
1994
Circulating Fibrocytes Define a New Leukocyte Subpopulation That Mediates Tissue Repair
Bucala R, Spiegel L, Chesney J, Hogan M, Cerami A. Circulating Fibrocytes Define a New Leukocyte Subpopulation That Mediates Tissue Repair. Molecular Medicine 1994, 1: 71-81. PMID: 8790603, PMCID: PMC2229929, DOI: 10.1007/bf03403533.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBone MarrowBone Marrow CellsCD4 AntigensCell AdhesionCells, CulturedCentrifugationChimeraCollagenConnective TissueCytoskeletonDNA-Binding ProteinsDose-Response Relationship, RadiationFemaleFibroblastsFlow CytometryFluorescent Antibody TechniqueHumansImmunohistochemistryLeukocytesMaleMiceMice, Inbred BALB CMicroscopy, ElectronMolecular Sequence DataNuclear ProteinsPhenotypeSex-Determining Region Y ProteinTime FactorsTranscription FactorsTransplantation, HeterologousVimentinWound HealingConceptsTissue injuryLeukocyte subpopulationsScar formationLong-term remodelingFibroblast-like propertiesNormal wound repairConnective tissue scarConnective tissue elementsCell typesFibrotic responseTissue scarWound chambersPathological fibrotic responsesHost responseInjuryConnective tissueFibrocytesWound repairFibroblast propertiesTissue repairTissue elementsDistinctive phenotypeSubpopulationsTissueNovel cell types