2024
Macrophage-derived macrophage migration inhibitory factor mediates renal injury in anti-glomerular basement membrane glomerulonephritis
Yang H, Li J, Huang X, Bucala R, Xu A, Lan H. Macrophage-derived macrophage migration inhibitory factor mediates renal injury in anti-glomerular basement membrane glomerulonephritis. Frontiers In Immunology 2024, 15: 1361343. PMID: 38846956, PMCID: PMC11153660, DOI: 10.3389/fimmu.2024.1361343.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorMigration inhibitory factorTreatment of immune-mediated kidney diseasesMacrophage MIFMIF depletionPathogenic roleSource of MIFImmune-mediated kidney diseasesAnti-glomerular basement membrane glomerulonephritisInhibitory factorT cell recruitmentGlomerular crescent formationTh17 immune responsesReduced serum creatininePolarization of macrophagesRenal macrophagesSerum creatinineCrescentic glomerulonephritisInhibiting Th1Renal injuryControl miceCreatine clearanceCrescent formationMembranous glomerulonephritisConditional ablation
1998
Reversal of Established Rat Crescentic Glomerulonephritis by Blockade of Macrophage Migration Inhibitory Factor (MIF): Potential Role of MIF in Regulating Glucocorticoid Production
Yang N, Nikolic-Paterson D, Ng Y, Mu W, Metz C, Bacher M, Meinhardt A, Bucala R, Atkins R, Lan H. Reversal of Established Rat Crescentic Glomerulonephritis by Blockade of Macrophage Migration Inhibitory Factor (MIF): Potential Role of MIF in Regulating Glucocorticoid Production. Molecular Medicine 1998, 4: 413-424. PMID: 10780884, PMCID: PMC2230272, DOI: 10.1007/bf03401748.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorCrescentic glomerulonephritisDay 7Ab treatmentRenal functionControl AbInhibitory factorPotent pro-inflammatory cytokineEndogenous glucocorticoid levelsIsotype control AbSevere renal injuryNormal renal functionCellular immune responsesPro-inflammatory cytokinesReversal of diseaseSerum corticosterone levelsExperimental crescentic glomerulonephritisInterleukin-1 productionRat crescentic glomerulonephritisCrescentic diseaseProgressive glomerulonephritisRenal injuryGBM glomerulonephritisLeukocyte infiltration
1997
TNF-α Up-regulates Renal MIF Expression in Rat Crescentic Glomerulonephritis
Lan H, Yang N, Metz C, Mu W, Song Q, Nikolic-Paterson D, Bacher M, Bucala R, Atkins R. TNF-α Up-regulates Renal MIF Expression in Rat Crescentic Glomerulonephritis. Molecular Medicine 1997, 3: 136-144. PMID: 9085256, PMCID: PMC2230061, DOI: 10.1007/bf03401805.Peer-Reviewed Original ResearchConceptsRenal MIF expressionMigration inhibitory factorMIF expressionCrescentic glomerulonephritisRat crescentic glomerulonephritisMIF productionDay 1BackgroundMacrophage migration inhibitory factorSoluble TNF-α receptorTumor necrosis factor αResident kidney cellsSerum MIF levelsPotent proinflammatory mediatorPathogenesis of endotoxemiaNecrosis factor αInterstitial macrophage infiltrationTNF-α receptorExperimental crescentic glomerulonephritisMIF levelsMIF secretionRenal injuryRenal damageRenal diseaseProinflammatory mediatorsMacrophage accumulation