2022
Macrophage Migration Inhibitory Factor (MIF) Promotes Increased Proportions of the Highly Permissive Th17-like Cell Profile during HIV Infection
Trifone C, Baquero L, Czernikier A, Benencio P, Leng L, Laufer N, Quiroga MF, Bucala R, Ghiglione Y, Turk G. Macrophage Migration Inhibitory Factor (MIF) Promotes Increased Proportions of the Highly Permissive Th17-like Cell Profile during HIV Infection. Viruses 2022, 14: 2218. PMID: 36298774, PMCID: PMC9611675, DOI: 10.3390/v14102218.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMIF stimulationMIF treatmentIL-17AHIV infectionMIF/CD74 axisFounder HIV-1Functionality of CD4Higher IL-17AHigher MIF concentrationsMIF plasma levelsHIV-1 infectionMigration inhibitory factorPossible therapeutic targetMIF concentrationsIntracellular cytokinesR5-tropicCytokine productionIL-1βIL-6IL-8Plasma levelsHealthy donorsViral persistenceT lymphocytes
2012
40. Antidepressant effects of macrophage migration inhibitory factor using a knockout mouse approach
Bay-Richter C, Janelidze S, Bucala R, Deierborg T, Brundin L. 40. Antidepressant effects of macrophage migration inhibitory factor using a knockout mouse approach. Brain Behavior And Immunity 2012, 26: s11-s12. DOI: 10.1016/j.bbi.2012.07.064.Peer-Reviewed Original ResearchSucrose preference testAntidepressant effectsIL-1βIL-6Male KOMacrophage migration inhibitory factorClear antidepressant effectMIF knockout miceLevels of IFNBrain mRNA expressionMigration inhibitory factorSuppression of IFNIL-6 mRNAIL-12p70Immune alterationsIL-10Female KOPlasma levelsSwim testKO miceSucrose preferenceDepressed patientsWildtype miceKO animalsWildtype littermates
1985
Non‐enzymatic modification of proteins by steroids: Pathological implications for autoimmunity and glucocorticoid toxicity
Bucala R, Cerami A. Non‐enzymatic modification of proteins by steroids: Pathological implications for autoimmunity and glucocorticoid toxicity. BioEssays 1985, 3: 55-59. PMID: 3842583, DOI: 10.1002/bies.950030204.Peer-Reviewed Original ResearchConceptsOral contraceptive agentsElevated plasma levelsHigh steroid levelsGlucocorticoid toxicityPlasma levelsCovalent addition productsPathological sequelaeContraceptive agentsSteroid levelsCertain steroidsAddition productsSteroidsPathological implicationsRearrangement productsMicrosomal oxidationNon-enzymatic modification