2001
Fibrocytes induce an angiogenic phenotype in cultured endothelial cells and promote angiogenesis in vivo
Hartlapp I, Abe R, Saeed R, Peng T, Voelter W, Bucala R, Metz C. Fibrocytes induce an angiogenic phenotype in cultured endothelial cells and promote angiogenesis in vivo. The FASEB Journal 2001, 15: 2215-2224. PMID: 11641248, DOI: 10.1096/fj.01-0049com.Peer-Reviewed Original ResearchConceptsBlood vessel formationAngiogenic phenotypeVessel formationMesenchymal cell typesEndothelial cell invasionEndothelial cellsExtracellular matrix-degrading enzymesEndothelial cell migrationGrowth factorCellular microenvironmentMatrix-degrading enzymesCell invasionCell migrationCell typesCultured endothelial cellsTube formationHematopoietic growth factorsPromotion of angiogenesisPhenotypeAngiogenesis modelMicrovascular endothelial cellsCultured fibrocytesEnzymeAngiogenesisVivo
1999
An Essential Role for Macrophage Migration Inhibitory Factor (MIF) in Angiogenesis and the Growth of a Murine Lymphoma
Chesney J, Metz C, Bacher M, Peng T, Meinhardt A, Bucala R. An Essential Role for Macrophage Migration Inhibitory Factor (MIF) in Angiogenesis and the Growth of a Murine Lymphoma. Molecular Medicine 1999, 5: 181-191. PMID: 10404515, PMCID: PMC2230298, DOI: 10.1007/bf03402061.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesCell DivisionCollagenDisease Models, AnimalDrug CombinationsEndothelium, VascularHumansImmunohistochemistryLamininLymphoma, B-CellMacrophage Migration-Inhibitory FactorsMiceMice, Inbred StrainsNeovascularization, PathologicOligonucleotides, AntisenseProteoglycansTumor Cells, CulturedConceptsMacrophage migration inhibitory factorRole of MIFAnti-MIF monoclonal antibodyMigration inhibitory factorB-cell lymphomaMonoclonal antibodiesCell lymphomaEffect of MIFBackgroundMacrophage migration inhibitory factorInhibitory factorC3H/HeN miceTumor-associated neovasculatureActivation of macrophagesAutocrine growth factorMicrovascular endothelial cellsCultured microvascular endothelial cellsAnti-neoplastic agentsNew blood vessel formationSolid tumor biologyEndothelial cell proliferationMIF expressionHeN miceSyngeneic modelMIF proteinTumor response