2001
Macrophage migration inhibitory factor is an important mediator in the pathogenesis of gastric inflammation in rats
Huang X, Hui C, Chen Y, Chun B, Wong Y, Fung P, Metz C, Cho C, Hui W, Bucala R, Lam S, Lan H. Macrophage migration inhibitory factor is an important mediator in the pathogenesis of gastric inflammation in rats. Gastroenterology 2001, 121: 619-630. PMID: 11522746, DOI: 10.1053/gast.2001.27205.Peer-Reviewed Original ResearchMeSH KeywordsAcetic AcidAcute DiseaseAnimalsAntibodies, MonoclonalDisease Models, AnimalGastritisGene ExpressionIn Situ HybridizationIn Vitro TechniquesIntercellular Adhesion Molecule-1Macrophage Migration-Inhibitory FactorsMacrophagesMaleNeutrophilsNitric Oxide SynthaseNitric Oxide Synthase Type IIRatsRats, Sprague-DawleyRNA, MessengerStomach UlcerTumor Necrosis Factor-alphaWound HealingConceptsAcute gastric ulcerMigration inhibitory factorInducible nitric oxide synthaseGastric ulcerNitric oxide synthaseGastric inflammationMIF antibodyOxide synthaseRole of MIFRat gastric ulcer modelsInhibitory factorMacrophage migration inhibitory factorIntercellular adhesion molecule-1Tumor necrosis factor alphaGastric ulcer modelImmune-mediated diseasesKey inflammatory mediatorsMajor inflammatory cellsAccumulation of macrophagesNecrosis factor alphaAdhesion molecule-1Sites of inflammationNeutrophil accumulationMIF productionUlcer size
1997
The Pathogenic Role of Macrophage Migration Inhibitory Factor in Immunologically Induced Kidney Disease in the Rat
Lan H, Bacher M, Yang N, Mu W, Nikolic-Paterson D, Metz C, Meinhardt A, Bucala R, Atkins R. The Pathogenic Role of Macrophage Migration Inhibitory Factor in Immunologically Induced Kidney Disease in the Rat. Journal Of Experimental Medicine 1997, 185: 1455-1466. PMID: 9126926, PMCID: PMC2196273, DOI: 10.1084/jem.185.8.1455.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAntibody FormationCell Adhesion MoleculesGene ExpressionGlomerulonephritisHypersensitivity, DelayedIntercellular Adhesion Molecule-1Interleukin-1Macrophage Migration-Inhibitory FactorsMaleMiceNitric Oxide SynthaseRabbitsRatsRats, Sprague-DawleyRNA, MessengerSkinTime FactorsVascular Cell Adhesion Molecule-1ConceptsMacrophage migration inhibitory factorControl antibody-treated animalsDelayed-type hypersensitivity responseAnti-MIF treatmentAntibody-treated animalsMigration inhibitory factorAdhesion molecule-1Hypersensitivity responseKidney diseaseLeukocytic infiltrationHistological damageCrescentic anti-glomerular basement membrane (GBM) glomerulonephritisMolecule-1Skin delayed-type hypersensitivity responseInducible nitric oxide synthase (iNOS) expressionAnti-glomerular basement membrane glomerulonephritisInhibitory factorVascular cell adhesion molecule-1Nitric oxide synthase expressionIntercellular adhesion molecule-1Cell adhesion molecule-1Rabbit anti-rat GBM serumProgressive renal injuryRenal function impairmentAnti-GBM glomerulonephritis
1996
Delayed‐type hypersensitivity mediates Bowman's capsule rupture in Tamm—Horsfall protein‐induced tubulointerstitial nephritis in the rat
Qing S, NIKOLIC‐PATERSON D, ATKINS R, BACHER M, BUCALA R, Hui Y. Delayed‐type hypersensitivity mediates Bowman's capsule rupture in Tamm—Horsfall protein‐induced tubulointerstitial nephritis in the rat. Nephrology 1996, 2: 417-427. DOI: 10.1111/j.1440-1797.1996.tb00123.x.Peer-Reviewed Original ResearchBowman's capsule ruptureTamm-Horsfall proteinCapsule ruptureBowman's capsuleT cellsCapsule integrityTubulointerstitial nephritisWeek 26Immune responseSkin delayed-type hypersensitivity responseDelayed-type hypersensitivity responseCytokine macrophage migration inhibitory factorMacrophage migration inhibitory factorIntercellular adhesion molecule-1Interstitial T cellsDelayed-type hypersensitivityCellular immune responsesHumoral immune responseMigration inhibitory factorAdhesion molecule-1Site of ruptureIntact Bowman's capsuleRat crescentic glomerulonephritisGroups of animalsMacrophage-like cells