2009
Macrophage migration inhibitory factor and multiple organ dysfunction syndrome
Yende S, Angus D, Bucala R. Macrophage migration inhibitory factor and multiple organ dysfunction syndrome. Journal Of Organ Dysfunction 2009, 5: 10-16. DOI: 10.1080/17471060802443653.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorMigration inhibitory factorSevere sepsisOrgan dysfunctionInhibitory factorMultiple organ dysfunction syndromeOrgan dysfunction syndromeInnate immune responseDysfunction syndromePoor outcomeCertain infectionsImmune responseHuman studiesSepsisDetrimental roleKey mediatorDysfunctionImportant predictorCritical roleDetrimental effectsGlucocorticoidsSyndromeInfection
2003
Chapter 45 Macrophage migration inhibitory factor (MIF)
Arenberg D, Bucala R. Chapter 45 Macrophage migration inhibitory factor (MIF). 2003, II: 1037-xxxiii. DOI: 10.1016/b978-012689663-3/50049-1.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorMigration inhibitory factorRegulation of MIFCritical pro-inflammatory mediatorInhibitory factorPro-inflammatory mediatorsMIF receptorImmune cellsImmunosuppressive propertiesCellular proliferationWidespread expressionMediatorsFuture investigationsCellsInflammationCytokinesGlucocorticoidsPathogenesisSteroidsSecretionActivityImportant roleReceptors
1998
Neuroimmunomodulation by Macrophage Migration Inhibitory Factor (MIF)
BUCALA R. Neuroimmunomodulation by Macrophage Migration Inhibitory Factor (MIF). Annals Of The New York Academy Of Sciences 1998, 840: 74-82. PMID: 9629239, DOI: 10.1111/j.1749-6632.1998.tb09551.x.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorImmune responseRole of MIFInhibitory factorT cell cytokine productionAnti-inflammatory propertiesAnterior pituitary cellsT-lymphocyte factorSteroid therapyLymph nodesCytokine productionImmunosuppressive effectsInflammatory conditionsGlucocorticoid actionT cellsFirst cytokineInflammatory sitesTherapeutic strategiesProinflammatory stimuliPituitary cellsImmune systemLymphocyte factorsGlucocorticoidsInhibitory effectRegulation of the immune response by macrophage migration inhibitory factor: biological and structural features
Bernhagen J, Calandra T, Bucala R. Regulation of the immune response by macrophage migration inhibitory factor: biological and structural features. Journal Of Molecular Medicine 1998, 76: 151-161. PMID: 9535548, DOI: 10.1007/s001090050204.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorInhibitory factorCytokine macrophage migration inhibitory factorDelayed-type hypersensitivity reactionNegative septic shockB cell responsesMIF productionSeptic shockImmunosuppressive effectsHypersensitivity reactionsImmune responseImmunological functionsCell responsesHost macrophagesCritical mediatorGlucocorticoidsMediatorsBiological roleResponseCytokine structureCytokinesDiseaseMacrophagesStress response
1997
Macrophage migration inhibitory factor: a regulator of glucocorticoid activity with a critical role in inflammatory disease
Donnelly S, Bucala R. Macrophage migration inhibitory factor: a regulator of glucocorticoid activity with a critical role in inflammatory disease. Trends In Molecular Medicine 1997, 3: 502-507. PMID: 9430786, DOI: 10.1016/s1357-4310(97)01133-7.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorAcute respiratory distress syndromeRelease of MIFFunction of MIFEfficacy of glucocorticoidsRespiratory distress syndromeAnti-inflammatory effectsMigration inhibitory factorEffects of glucocorticoidsAnterior pituitary glandARDS pathogenesisDistress syndromeGlucocorticoid activityInflammatory diseasesT cellsFirst cytokineInflammatory sitesPituitary glandInhibitory factorGlucocorticoidsCritical rolePhysiological responsesCytokinesPathogenesisSyndromeRegulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome
Donnelly S, Haslett C, Reid P, Grant I, Wallace W, Metz C, Bruce L, Bucala R. Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome. Nature Medicine 1997, 3: 320-323. PMID: 9055860, DOI: 10.1038/nm0397-320.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeMigration inhibitory factorRespiratory distress syndromeDistress syndromeSignificant pro-inflammatory effectsInhibitory factorMacrophage migration inhibitory factorPro-inflammatory cytokine secretionPulmonary inflammatory responseAnti-inflammatory actionAnti-inflammatory effectsPro-inflammatory effectsIL-8 secretionConcentration-related fashionNovel therapeutic approachesInflammatory diseasesCytokine secretionInflammatory responseTherapeutic approachesAlveolar airspaceAlveolar cellsPatientsGlucocorticoidsSyndromeSecretionRole of Macrophage Migration Inhibitory Factor in the Regulation of the Immune Response
Metz C, Bucala R. Role of Macrophage Migration Inhibitory Factor in the Regulation of the Immune Response. Advances In Immunology 1997, 66: 197-223. PMID: 9328642, DOI: 10.1016/s0065-2776(08)60598-2.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorT cellsImmune responseInhibitory factorAnti-inflammatory effectsInflammatory disease statesAnterior pituitary glandSeptic shockMIF actionMIF proteinInflammatory responseGlucocorticoid actionImmune systemPituitary glandCorticotrophic cellsGlucocorticoidsInhibitory effectDisease statesBaseline statePotential roleMacrophagesCellsResponseArthritis
1995
MIF as a glucocorticoid-induced modulator of cytokine production
Calandra T, Bernhagen J, Metz C, Spiegel L, Bacher M, Donnelly T, Cerami A, Bucala R. MIF as a glucocorticoid-induced modulator of cytokine production. Nature 1995, 377: 68-71. PMID: 7659164, DOI: 10.1038/377068a0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell LineCytokinesDexamethasoneEnzyme-Linked Immunosorbent AssayFemaleGlucocorticoidsHumansHydrocortisoneImmunityInflammationLipopolysaccharidesMacrophage ActivationMacrophage Migration-Inhibitory FactorsMacrophagesMiceMice, Inbred BALB CRatsRats, Sprague-DawleyRecombinant ProteinsShock, SepticT-LymphocytesConceptsMacrophage migration inhibitory factorCounter-regulatory systemsMigration inhibitory factorProtein macrophage migration inhibitory factorGlucocorticoid protectionLethal endotoxaemiaMIF productionCytokine productionCytokine secretionMacrophage cytokinesEndogenous mediatorsImmunosuppressive propertiesImmune responseGlucocorticoid hormonesInhibitory factorHormonal systemsCritical mediatorUnexpected findingMediatorsVital functionsEndotoxaemiaCytokinesGlucocorticoidsMonocytesPituitary
1985
Glucocorticoid-lens protein adducts in experimentally induced steroid cataracts
Bucala R, Callati M, Manabe S, Cotlier E, Cerami A. Glucocorticoid-lens protein adducts in experimentally induced steroid cataracts. Experimental Eye Research 1985, 40: 853-863. PMID: 4018168, DOI: 10.1016/0014-4835(85)90130-7.Peer-Reviewed Original ResearchNonenzymatic modification of lens crystallins by prednisolone induces sulfhydryl oxidation and aggregate formation: In vitro and in vivo studies
Bucala R, Manabe S, Urban R, Cerami A. Nonenzymatic modification of lens crystallins by prednisolone induces sulfhydryl oxidation and aggregate formation: In vitro and in vivo studies. Experimental Eye Research 1985, 41: 353-363. PMID: 4065253, DOI: 10.1016/s0014-4835(85)80026-9.Peer-Reviewed Original ResearchConceptsSteroid-induced cataractPossible pharmacological strategiesSteroid therapyLens crystallinsPharmacological strategiesLens opacitiesNonenzymatic modificationGlucocorticoid prednisoloneToxic manifestationsTherapeutic levelsPrednisoloneCataractogenic effectVivo studiesGlucocorticoidsCataractLens proteinsSulfhydryl oxidationGel filtration chromatographyPrevious studiesAddition of dithiothreitol