2022
CD74 as a regulator of transcription in normal B cells
David K, Friedlander G, Pellegrino B, Radomir L, Lewinsky H, Leng L, Bucala R, Becker-Herman S, Shachar I. CD74 as a regulator of transcription in normal B cells. Cell Reports 2022, 41: 111572. PMID: 36323260, DOI: 10.1016/j.celrep.2022.111572.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorNormal B cellsB cellsCytokine macrophage migration inhibitory factorRegulators of transcriptionChronic lymphocytic leukemia cellsMigration inhibitory factorNovel therapeutic pathwaysInhibition of transcriptionLymphocytic leukemia cellsTumor suppressor geneTranscriptional regulatorsTranscription factorsTherapeutic pathwaysCLL cellsFuture treatmentIntracellular domainOncogenic transformationMalignant cellsInhibitory factorRegulatory functionsPromoter areaLeukemia cellsTranscriptionGenes
2013
CD84 is a survival receptor for chronic lymphocytic leukemia cells (P2044)
Marom A, Binsky-Ehrenreich I, Sobotta M, Shvidel L, Berrebi A, Hazan-Halevy I, Kay S, Aloshin A, Sagi I, Goldenberg D, Leng L, Bucala R, Herishanu Y, Haran M, Shachar I. CD84 is a survival receptor for chronic lymphocytic leukemia cells (P2044). The Journal Of Immunology 2013, 190: 132.12-132.12. DOI: 10.4049/jimmunol.190.supp.132.12.Peer-Reviewed Original ResearchChronic lymphocytic leukemiaMacrophage migration inhibitory factorBone marrowAbstract Chronic lymphocytic leukemiaChronic lymphocytic leukemia cellsMigration inhibitory factorCLL cell survivalNovel therapeutic strategiesLymphocytic leukemia cellsCD84 expressionPeripheral bloodLymphoid organsMcl-1 expressionClinical trialsLymphocytic leukemiaCLL cellsTherapeutic strategiesB lymphocytesMalignant cellsInhibitory factorInduces cell deathSurvival receptorCD84Leukemia cellsProtein levels