2024
TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCα-HuR axis in rheumatoid arthritis
Lin Y, Chen Y, Hu W, Liu X, Hao W, Xing J, Ding J, Xu Y, Yao F, Zhao Y, Wang K, Li S, Yu Q, Hu W, Zhou R. TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCα-HuR axis in rheumatoid arthritis. International Immunopharmacology 2024, 132: 111933. PMID: 38581988, DOI: 10.1016/j.intimp.2024.111933.Peer-Reviewed Original ResearchConceptsTransient receptor potential melastatin 7Rheumatoid arthritisInhibition of transient receptor potential melastatin 7Human RA patientsSynovial hyperplasiaAdjuvant-induced arthritis ratsIncreased TRPM7 expressionIL-6 mRNATreatment of RAPathogenesis of RAFibroblast-like synoviocytesTRPM7 silencingProgression of rheumatoid arthritisTRPM7 expressionChannel inhibitionCation channelsRA patientsMetastasisPharmacological inhibitionArthritis ratsInflammationNuclear translocationSynoviocyte proliferationHyperplasiaProliferation
2022
Regulatory role of KCa3.1 in immune cell function and its emerging association with rheumatoid arthritis
Lin Y, Zhao Y, Zhang H, Hao W, Zhu R, Wang Y, Hu W, Zhou R. Regulatory role of KCa3.1 in immune cell function and its emerging association with rheumatoid arthritis. Frontiers In Immunology 2022, 13: 997621. PMID: 36275686, PMCID: PMC9580404, DOI: 10.3389/fimmu.2022.997621.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisSynovial inflammationImmune cellsCollagen antibody-induced arthritis modelAntibody-induced arthritis modelCartilage/bone destructionPathogenesis of RACommon autoimmune diseaseImmune cell functionPotential therapeutic targetIntermediate-conductance CaImmune balanceRA patientsBone destructionImmune dysfunctionChronic inflammationArthritis modelAutoimmune diseasesPeripheral bloodArticular synoviumPathological progressionCartilage damageKCa3.1 channelsTherapeutic targetAbnormal activationCalcium-Permeable Channels Cooperation for Rheumatoid Arthritis: Therapeutic Opportunities
Liang H, Yin H, Li S, Chen Y, Zhao Y, Hu W, Zhou R. Calcium-Permeable Channels Cooperation for Rheumatoid Arthritis: Therapeutic Opportunities. Biomolecules 2022, 12: 1383. PMID: 36291594, PMCID: PMC9599458, DOI: 10.3390/biom12101383.Peer-Reviewed Original ResearchConceptsPathogenesis of RARheumatoid arthritisCalcium-permeable channelsIntra-articular inflammationCommon autoimmune diseaseTreatment of RAEntry of CaDrug targetsSynovial invasionPatients' qualityAutoimmune diseasesNovel drug targetsCartilage damageArthritisTherapeutic opportunitiesPathological processesCalcium signalingInflammationPathogenesisSpecific roleRAHuman cellsTargetCell membraneDisease
2016
Functions of interleukin‐34 and its emerging association with rheumatoid arthritis
Zhou R, Wu X, Xie Y, Dai B, Hu W, Ge J, Chen F. Functions of interleukin‐34 and its emerging association with rheumatoid arthritis. Immunology 2016, 149: 362-373. PMID: 27550090, PMCID: PMC5095491, DOI: 10.1111/imm.12660.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisIL-34Inflammatory arthritisAutoimmune diseasesDevelopment of RAInterleukin-34Active rheumatoid arthritisSystemic autoimmune diseaseEffective treatment optionExtra-articular lesionsNovel therapeutic strategiesMononuclear phagocyte lineage cellsSynovial inflammationTreatment optionsSpecific monoclonal antibodiesTherapeutic strategiesTherapeutic targetArthritisMonoclonal antibodiesExperimental modelLineage cellsMultiple jointsReceptor ligandsInflammationDisease