2018
Acute Ethanol Exposure Promotes Autophagy-Lysosome Pathway-Dependent ASIC1a Protein Degradation and Protects Against Acidosis-Induced Neurotoxicity
Zhou R, Leng T, Yang T, Chen F, Xiong Z. Acute Ethanol Exposure Promotes Autophagy-Lysosome Pathway-Dependent ASIC1a Protein Degradation and Protects Against Acidosis-Induced Neurotoxicity. Molecular Neurobiology 2018, 56: 3326-3340. PMID: 30120732, PMCID: PMC6378129, DOI: 10.1007/s12035-018-1289-0.Peer-Reviewed Original ResearchConceptsAcid-sensing ion channel 1aAutophagy-lysosome pathwayNeuronal cellsAcidosis-induced cytotoxicityAcute ethanol administrationAcute ethanol exposureActivity/expressionEthanol-induced reductionIon channel 1aAutophagy activator rapamycinAutophagy inhibitor CQEffects of ethanolASIC1a expressionIschemic strokeNeuronal injuryAcute treatmentBrain ischemiaNeuroprotective effectsEthanol administrationASIC currentsEthanol exposureTissue acidosisASIC1a channelsChannel 1aNeurotoxicity
2015
Interleukin-6 enhances acid-induced apoptosis via upregulating acid-sensing ion channel 1a expression and function in rat articular chondrocytes
Zhou R, Wu X, Wang Z, Ge J, Chen F. Interleukin-6 enhances acid-induced apoptosis via upregulating acid-sensing ion channel 1a expression and function in rat articular chondrocytes. International Immunopharmacology 2015, 29: 748-760. PMID: 26359543, DOI: 10.1016/j.intimp.2015.08.044.Peer-Reviewed Original ResearchMeSH KeywordsAcid Sensing Ion ChannelsAcidsAnimalsAntibodies, Monoclonal, HumanizedApoptosisApoptosis Regulatory ProteinsArthritis, ExperimentalCartilage, ArticularChondrocytesDose-Response Relationship, DrugEnzyme ActivationInterleukin-6L-Lactate DehydrogenaseMalePeptidesRatsRats, Sprague-DawleySpider VenomsUp-RegulationConceptsInflammatory cytokine interleukin-6Acid-sensing ion channelsArticular chondrocyte apoptosisRat articular chondrocytesChondrocyte apoptosisRheumatoid arthritisAcid-induced cell injuryArticular chondrocytesAdjuvant arthritis ratsPrimary rat articular chondrocytesChronic inflammatory diseaseCytokine interleukin-6IL-6 receptorJAK2/STAT3Dose-dependent mannerArthritis ratsInflammatory diseasesInterleukin-6Specific antagonistCell injuryNF-κBAcid-induced apoptosisLDH releaseArthritic cartilageDownregulated expression