Role of eIF3a in 4-amino-2-trifluoromethyl-phenyl retinate-induced cell differentiation in human chronic myeloid leukemia K562 cells
Li G, Wang K, Li Y, Ruan J, Wang C, Qian Y, Zu S, Dai B, Meng Y, Zhou R, Ge J, Chen F. Role of eIF3a in 4-amino-2-trifluoromethyl-phenyl retinate-induced cell differentiation in human chronic myeloid leukemia K562 cells. Gene 2018, 683: 195-209. PMID: 30340049, DOI: 10.1016/j.gene.2018.10.035.Peer-Reviewed Original ResearchConceptsMyeloid differentiation marker CD11bCyclin D1Trans retinoic acid (ATRA) derivativeK562 cellsAnti-tumor effectsChronic myeloid leukemia K562 cellsMyeloid leukemia cell differentiationRetinoic acid derivativesCell differentiationG0/G1 phaseExpression of eIF3aC-MycHuman chronic myeloid leukemia K562 cellsDifferentiation marker CD11bTumor cell proliferationRole of eIF3aActivation of ERK1/2Marker CD11bCML cellsLeukemia cell differentiationP-ERKLeukemia K562 cellsPhenyl retinateP-RafEIF3a expression4-Amino-2-Trifluoromethyl-Phenyl Retinate induced leukemia cell differentiation by decreasing eIF6
Wang K, Wang C, Zhu C, Li G, Li Y, Feng Y, Ruan J, Zhu F, Meng Y, Zhou R, Chen F. 4-Amino-2-Trifluoromethyl-Phenyl Retinate induced leukemia cell differentiation by decreasing eIF6. Biochemical And Biophysical Research Communications 2018, 503: 2033-2039. PMID: 30078681, DOI: 10.1016/j.bbrc.2018.07.153.Peer-Reviewed Original ResearchConceptsLeukemia cell differentiationTrans retinoic acid (ATRA) derivativeEukaryotic translation initiation factor 6Cell proliferationEffects of ATPRRetinoic acid derivativesCell differentiationSurface antigen CD11bDifferentiation of K562Potential molecular mechanismsProliferation of K562Leukemia cell linesPhenyl retinateATPRInnovative treatmentsLeukemia cellsCell surface antigen CD11bCell linesC-MycFactor 6Induced differentiationK562ProliferationMolecular mechanismsCBF