2021
Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases
Liang H, Chen Y, Wei X, Ma G, Ding J, Lu C, Zhou R, Hu W. Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases. Immunology 2021, 165: 3-21. PMID: 34558663, DOI: 10.1111/imm.13420.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmune DiseasesAutoimmunityBiomarkersDisease SusceptibilityDrug DevelopmentGene Expression RegulationHumansImmune SystemImmunomodulationIon Channel GatingOrgan SpecificityProtein Kinase InhibitorsProtein Serine-Threonine KinasesSignal TransductionStructure-Activity RelationshipTRPM Cation ChannelsConceptsAutoimmune diseasesRole of TRPM7New treatment targetsPotential therapeutic targetReceptor ion channelsImmune toleranceRheumatoid arthritisMultiple sclerosisSystemic disordersBody of evidenceImmune cellsCytokine secretionImmunoreactive substancesFunctional damageImmunomodulatory functionsTherapeutic targetTreatment targetsDiseaseEffective interventionsPharmacological propertiesOne-tissueTRPM7Physiologic conditionsInappropriate responsesCell migration
2015
Novel Insights into Acid-Sensing Ion Channels: Implications for Degenerative Diseases.
Zhou R, Wu X, Wang Z, Xie Y, Ge J, Chen F. Novel Insights into Acid-Sensing Ion Channels: Implications for Degenerative Diseases. Aging And Disease 2015, 7: 491-501. PMID: 27493834, PMCID: PMC4963192, DOI: 10.14336/ad.2015.1213.Peer-Reviewed Original ResearchAcid-sensing ion channelsDegenerative diseasesActivation of ASICsEffective treatment optionIon channelsLigand-gated ion channelsIntervertebral disc degenerationMultiple sclerosisTreatment optionsParkinson's diseaseTherapeutic targetDegenerative disordersDisc degenerationProgressive deteriorationDiseaseAberrant activationHuntington's diseaseOlder adultsCritical roleCell apoptosisPathological conditionsOrgan degenerationDegenerationPotential utilityActivation