2024
Ion channels in osteoarthritis: emerging roles and potential targets
Zhou R, Fu W, Vasylyev D, Waxman S, Liu C. Ion channels in osteoarthritis: emerging roles and potential targets. Nature Reviews Rheumatology 2024, 20: 545-564. PMID: 39122910, DOI: 10.1038/s41584-024-01146-0.Peer-Reviewed Original ResearchIon channelsVoltage-dependent calcium channelsAcid-sensing ion channelsTransient receptor potential channelsVoltage-gated sodium channelsIon channel modulatorsFunction of ion channelsPotential clinical applicationsCalcium channelsPreclinical studiesClinical impactSymptomatic reliefPotassium channelsChloride channelsDisease-modifying treatmentsClinical trialsSodium channelsBone hyperplasiaChannel modulationIon channel biologySynovial inflammationClinical applicationPiezo channelsModel of OAPotential target
2015
Novel Insights into Acid-Sensing Ion Channels: Implications for Degenerative Diseases.
Zhou R, Wu X, Wang Z, Xie Y, Ge J, Chen F. Novel Insights into Acid-Sensing Ion Channels: Implications for Degenerative Diseases. Aging And Disease 2015, 7: 491-501. PMID: 27493834, PMCID: PMC4963192, DOI: 10.14336/ad.2015.1213.Peer-Reviewed Original ResearchAcid-sensing ion channelsDegenerative diseasesActivation of ASICsEffective treatment optionIon channelsLigand-gated ion channelsIntervertebral disc degenerationMultiple sclerosisTreatment optionsParkinson's diseaseTherapeutic targetDegenerative disordersDisc degenerationProgressive deteriorationDiseaseAberrant activationHuntington's diseaseOlder adultsCritical roleCell apoptosisPathological conditionsOrgan degenerationDegenerationPotential utilityActivation