2016
Functions of interleukin‐34 and its emerging association with rheumatoid arthritis
Zhou R, Wu X, Xie Y, Dai B, Hu W, Ge J, Chen F. Functions of interleukin‐34 and its emerging association with rheumatoid arthritis. Immunology 2016, 149: 362-373. PMID: 27550090, PMCID: PMC5095491, DOI: 10.1111/imm.12660.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisIL-34Inflammatory arthritisAutoimmune diseasesDevelopment of RAInterleukin-34Active rheumatoid arthritisSystemic autoimmune diseaseEffective treatment optionExtra-articular lesionsNovel therapeutic strategiesMononuclear phagocyte lineage cellsSynovial inflammationTreatment optionsSpecific monoclonal antibodiesTherapeutic strategiesTherapeutic targetArthritisMonoclonal antibodiesExperimental modelLineage cellsMultiple jointsReceptor ligandsInflammationDisease
2015
Novel Insights into Acid-Sensing Ion Channels: Implications for Degenerative Diseases.
Zhou R, Wu X, Wang Z, Xie Y, Ge J, Chen F. Novel Insights into Acid-Sensing Ion Channels: Implications for Degenerative Diseases. Aging And Disease 2015, 7: 491-501. PMID: 27493834, PMCID: PMC4963192, DOI: 10.14336/ad.2015.1213.Peer-Reviewed Original ResearchAcid-sensing ion channelsDegenerative diseasesActivation of ASICsEffective treatment optionIon channelsLigand-gated ion channelsIntervertebral disc degenerationMultiple sclerosisTreatment optionsParkinson's diseaseTherapeutic targetDegenerative disordersDisc degenerationProgressive deteriorationDiseaseAberrant activationHuntington's diseaseOlder adultsCritical roleCell apoptosisPathological conditionsOrgan degenerationDegenerationPotential utilityActivation