Highly immunoreactive antibodies against the rHup-F2 fragment (aa 63–161) of the iron-regulated HupB protein of Mycobacterium tuberculosis and its potential for the serodiagnosis of extrapulmonary and recurrent tuberculosis
Sritharan N, Choudhury M, Sivakolundu S, Chaurasia R, Chouhan N, Rao P, Sritharan M. Highly immunoreactive antibodies against the rHup-F2 fragment (aa 63–161) of the iron-regulated HupB protein of Mycobacterium tuberculosis and its potential for the serodiagnosis of extrapulmonary and recurrent tuberculosis. European Journal Of Clinical Microbiology & Infectious Diseases 2014, 34: 33-40. PMID: 25037869, DOI: 10.1007/s10096-014-2203-y.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayTB patientsExtrapulmonary tuberculosisPulmonary tuberculosisHealthy controlsMycobacterium tuberculosisExtrapulmonary TB patientsNormal healthy controlsRecurrent tuberculosisHousehold contactsSerum ironEnhanced immunoreactivityTuberculosisImmunoreactive antibodyAntigenic fragmentsPatientsImmunosorbent assayM. tuberculosisDiagnostic potentialSerumAntigenAntibodiesNegative correlationNegligible levelsHigh levels