Cytotoxicity of the 42 kDa SMase C sphingomyelinase secreted by Leptospira interrogans serovar Pomona on Vero cells.
Chaurasia R, Sritharan M. Cytotoxicity of the 42 kDa SMase C sphingomyelinase secreted by Leptospira interrogans serovar Pomona on Vero cells. Microbiology 2020, 166: 1065-1073. PMID: 32985970, DOI: 10.1099/mic.0.000976.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacterial ProteinsCell DeathChlorocebus aethiopsCytotoxinsLeptospira interrogans serovar pomonaMolecular WeightProtein DomainsRecombinant ProteinsSphingomyelin PhosphodiesteraseSphingomyelinsVero CellsConceptsVero cellsSerovar PomonaHaemorrhagic manifestationsHost cell damageEarly diagnosisSevere formHuman patientsExperimental animalsLeptospira interrogansLeptospirosisCandidate markersSphingomyelinase activityHaemolytic activityPomonaSphingomyelinasePathogenic membersCytotoxicitySphingomyelinase geneActive formHigh levelsCellsPatientsDiagnosisConfocal imagesSphingomyelinases