2019
Targeting DNA repair in gliomas.
Beckta JM, Bindra RS, Chalmers AJ. Targeting DNA repair in gliomas. Current Opinion In Neurology 2019, 32: 878-885. PMID: 31592790, DOI: 10.1097/wco.0000000000000760.Peer-Reviewed Original ResearchConceptsLocal controlPoor local controlBlood-brain barrierTreatment of gliomaOverall survivalSystemic treatmentClinical outcomesDismal prognosisAggressive entityPreclinical dataPatient outcomesRadiation therapyGliomasOutcomesDNA repair targetsTreatmentRepair mechanismsRepair targetsNovel chemoCurrent understandingPatientsPrognosisDNA damage responseMalignancyRole of Radiation Therapy in the Management of Diffuse Intrinsic Pontine Glioma: A Systematic Review
Gallitto M, Lazarev S, Wasserman I, Stafford JM, Wolden SL, Terezakis SA, Bindra RS, Bakst RL. Role of Radiation Therapy in the Management of Diffuse Intrinsic Pontine Glioma: A Systematic Review. Advances In Radiation Oncology 2019, 4: 520-531. PMID: 31360809, PMCID: PMC6639749, DOI: 10.1016/j.adro.2019.03.009.Peer-Reviewed Original ResearchDiffuse intrinsic pontine gliomaIntrinsic pontine gliomaMedian overall survivalOverall survivalRadiation therapyPontine gliomaSystematic reviewSystemic therapyPrimary pediatric brain tumorsMainstay of treatmentSalvage radiation therapyConcomitant systemic therapyPediatric brain tumorsAppropriate treatment approachLarge systematic reviewGreat clinical needDIPG treatmentMedian OSRT regimensRetrospective seriesInitial diagnosisGlioma radiotherapyTreatment strategiesBrain tumorsTreatment approaches
2015
Adjuvant hypofractionated partial-brain radiation therapy for pediatric Ewing sarcoma brain metastases: case report.
van Dams R, Park HS, Alomari AK, Ricciardi AS, Rao H, McNamara J, DiLuna ML, Bindra RS. Adjuvant hypofractionated partial-brain radiation therapy for pediatric Ewing sarcoma brain metastases: case report. Journal Of Neurosurgery Pediatrics 2015, 17: 434-8. PMID: 26636250, DOI: 10.3171/2015.8.peds15313.Peer-Reviewed Original ResearchConceptsPartial brain radiation therapyRadiation therapyCase reportSarcoma brain metastasesEvidence of diseaseGross tumor resectionGross total resectionBrain metastasesInflammatory changesIntracranial metastasesSarcoma metastasisTumor resectionMetastasisTherapyResectionPatientsLimited marginReasonable approachReportDexamethasoneDiseaseGyBrainMonthsAdvances in Radiation Therapy in Pediatric Neuro-oncology
Bindra RS, Wolden SL. Advances in Radiation Therapy in Pediatric Neuro-oncology. Journal Of Child Neurology 2015, 31: 506-516. PMID: 26271789, DOI: 10.1177/0883073815597758.Peer-Reviewed Original ResearchConceptsPediatric central nervous system tumorsCentral nervous system tumorsNervous system tumorsSystem tumorsRadiation therapyPediatric neuro-oncologyLong-term survivalEffective therapyTreatment protocolNeuro-oncologyBrain tumorsTherapyPrecision treatmentTumorsMolecular classificationMore childrenHealthy tissueImage guidanceProton therapyLess exposureTreatmentDoses
2014
Delayed Cerebral Vasculopathy Following Cranial Radiation Therapy for Pediatric Tumors
Wang C, Roberts KB, Bindra RS, Chiang VL, Yu JB. Delayed Cerebral Vasculopathy Following Cranial Radiation Therapy for Pediatric Tumors. Pediatric Neurology 2014, 50: 549-556. PMID: 24739378, DOI: 10.1016/j.pediatrneurol.2013.09.018.Peer-Reviewed Original ResearchConceptsMedian interval periodIntracerebral hemorrhageMoyamoya syndromeInterval periodCranial radiation therapyRadiation doseIntracerebral hemorrhage casesMoyamoya casesCerebral vasculopathyCerebrovascular injuryMedian agePatient agePediatric patientsDoses of radiationDisease presentationPediatric tumorsRadiation therapyHemorrhage casesHemorrhagePatientsCerebrovasculopathySignificant associationMoyamoyaSyndromeTime of radiation
2011
The important role of radiation therapy in early-stage diffuse large B-cell lymphoma: time to review the evidence once again
Bindra RS, Yahalom J. The important role of radiation therapy in early-stage diffuse large B-cell lymphoma: time to review the evidence once again. Expert Review Of Anticancer Therapy 2011, 11: 1367-1378. PMID: 21929311, DOI: 10.1586/era.11.88.Peer-Reviewed Original ResearchConceptsEarly-stage diffuse large B-cell lymphomaDiffuse large B-cell lymphomaLarge B-cell lymphomaB-cell lymphomaLocalized diseaseClinical trialsRadiation therapyAlternative treatment regimenSignificant survival benefitCombined-modality therapyRecent clinical trialsRandomized clinical trialsCombination of chemotherapyIntensive immunochemotherapyConsolidation radiotherapySurvival benefitTreatment regimenRetrospective studyHodgkin's lymphomaMultimodality approachCommon subtypeSuperior efficacyLocal controlAppropriate managementLymphoma