2024
The Case | An active injection drug user with a skin rash and kidney failure
Aron A, Luciano R. The Case | An active injection drug user with a skin rash and kidney failure. Kidney International 2024, 105: 1327-1328. PMID: 38777409, DOI: 10.1016/j.kint.2024.03.009.Peer-Reviewed Original ResearchIdentification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2024, 134: e180583. PMID: 38488004, PMCID: PMC10940080, DOI: 10.1172/jci180583.Peer-Reviewed Original Research
2023
Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2023, 133: e168950. PMID: 37395276, PMCID: PMC10313360, DOI: 10.1172/jci168950.Peer-Reviewed Original ResearchConceptsUrinary CXCL9External validation cohortValidation cohortControl groupAIN diagnosisDiscovery cohortKidney tissueDiagnostic biomarkersAcute interstitial nephritisCXCL9 mRNA expressionAcute kidney injuryBiopsy-confirmed diagnosisAvailable clinical testsNational InstituteKidney injuryTubulointerstitial nephritisInterstitial nephritisKidney biopsyHistological confirmationHistological diagnosisTreatment optionsLymphocyte chemotaxisCXCL9MRNA expression differencesPatients
2022
Safety and Adequacy of Kidney Biopsy Procedure in Patients with Obesity
Qian L, Menez S, Hu D, Weinstein J, Melchinger H, Thiessen-Philbrook H, Luciano R, Turner J, Perazella M, Villalobos C, Shaw M, Wilson F, Parikh C, Moledina D. Safety and Adequacy of Kidney Biopsy Procedure in Patients with Obesity. Kidney360 2022, 4: 98-101. PMID: 36700910, PMCID: PMC10101611, DOI: 10.34067/kid.0006602022.Peer-Reviewed Original ResearchPeritoneal Dialysis Should Be Considered the First Option for Patients Requiring Urgent Start Dialysis: CON
Luciano R. Peritoneal Dialysis Should Be Considered the First Option for Patients Requiring Urgent Start Dialysis: CON. Kidney360 2022, 4: 138-140. PMID: 36821605, PMCID: PMC10103267, DOI: 10.34067/kid.0007822021.Peer-Reviewed Original Research
2014
Nephrotoxic effects of designer drugs: synthetic is not better!
Luciano RL, Perazella MA. Nephrotoxic effects of designer drugs: synthetic is not better! Nature Reviews Nephrology 2014, 10: 314-324. PMID: 24662435, DOI: 10.1038/nrneph.2014.44.BooksKidney Involvement in Leukemia and Lymphoma
Luciano RL, Brewster UC. Kidney Involvement in Leukemia and Lymphoma. Advances In Kidney Disease And Health 2014, 21: 27-35. PMID: 24359984, DOI: 10.1053/j.ackd.2013.07.004.BooksConceptsAcute kidney injuryKidney involvementOvert kidney failureAcute tubular necrosisMultiorgan system involvementLife-threatening consequencesForms of leukemiaAcid-base disordersObstructive etiologyKidney injuryElectrolyte disturbancesTubular necrosisCommon etiologyNephrotic syndromeKidney failureSystem involvementHematologic malignanciesSide effectsDirect effectMalignancyAge groupsLymphomaLeukemiaComplicationsEtiology
2013
Acute Kidney Injury From Cherry Concentrate in a Patient With CKD
Luciano RL. Acute Kidney Injury From Cherry Concentrate in a Patient With CKD. American Journal Of Kidney Diseases 2013, 63: 503-505. PMID: 24290246, DOI: 10.1053/j.ajkd.2013.09.021.Peer-Reviewed Case Reports and Technical NotesConceptsAcute kidney injuryKidney injuryKidney diseaseNonsteroidal anti-inflammatory medicationsAnti-inflammatory medicationsChronic kidney diseaseCherry concentrateMethod of injuryMultiple organ systemsMechanism of actionSignificant morbidityHarmful side effectsCyclooxygenase inhibitionNumerous health benefitsMedical foodsSide effectsOrgan systemsHyperkalemiaInjuryPatientsDaily consumptionAdverse effectsHealth benefitsCherry extractDiseaseExtra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management
Luciano RL, Dahl NK. Extra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management. Nephrology Dialysis Transplantation 2013, 29: 247-254. PMID: 24215018, DOI: 10.1093/ndt/gft437.Peer-Reviewed Educational MaterialsConceptsAutosomal dominant polycystic kidney diseaseEnd-stage renal diseaseChronic kidney diseaseExtra-renal manifestationsKidney diseasePolycystic kidney diseaseDisease burdenRenal cystsBilateral renal cystsCurrent screening recommendationsDominant polycystic kidney diseaseExtra-renal diseaseDiverticular diseaseRenal diseaseScreening recommendationsSystemic diseaseADPKD patientsRoutine screeningMale infertilityDiseaseProgressive increasePatientsCystsManifestationsBurdenBabesiosis-Induced Acute Kidney Injury With Prominent Urinary Macrophages
Luciano RL, Moeckel G, Palmer M, Perazella MA. Babesiosis-Induced Acute Kidney Injury With Prominent Urinary Macrophages. American Journal Of Kidney Diseases 2013, 62: 801-805. PMID: 23643302, DOI: 10.1053/j.ajkd.2013.02.376.Peer-Reviewed Case Reports and Technical NotesConceptsAcute kidney injuryAcute tubular injuryKidney injuryTubular injuryDialysis-requiring acute kidney injuryAcute interstitial nephritisMultiorgan system failureSubsequent kidney biopsySevere symptomatic diseaseUrinary macrophagesUrinary findingsInterstitial nephritisKidney biopsySymptomatic diseaseMassive hemolysisSevere babesiosisVolume depletionCommon causeProfound hemolysisErythrocyte fragmentsUrine sedimentInjuryLarge macrophagesPigment toxicityUnique finding
2012
A Dysfunctional Peritoneal Dialysis Catheter: Imaging the Problem
Luciano RL, Brewster UC. A Dysfunctional Peritoneal Dialysis Catheter: Imaging the Problem. Seminars In Dialysis 2012, 25: 560-561. PMID: 22780865, DOI: 10.1111/j.1525-139x.2012.01108.x.Peer-Reviewed Case Reports and Technical Notes
2011
Risk of Poor Outcomes with Novel and Traditional Biomarkers at Clinical AKI Diagnosis
Hall IE, Coca SG, Perazella MA, Eko UU, Luciano RL, Peter PR, Han WK, Parikh CR. Risk of Poor Outcomes with Novel and Traditional Biomarkers at Clinical AKI Diagnosis. Clinical Journal Of The American Society Of Nephrology 2011, 6: 2740-2749. PMID: 22034509, PMCID: PMC3255362, DOI: 10.2215/cjn.04960511.Peer-Reviewed Original ResearchConceptsKidney injury molecule-1Neutrophil gelatinase-associated lipocalinAcute kidney injuryAcute tubular necrosisMicroscopy scorePrimary outcomeIL-18Prognostic utilityClinical assessmentInjury molecule-1Peak serum creatinineProspective cohort studyGelatinase-associated lipocalinFirst dayUrine protein biomarkersProtein biomarker concentrationsAKI criteriaAKI diagnosisAKI stageBaseline GFRHospital deathKidney injuryCohort studySerum creatinineTubular necrosis
2000
Carboxy Terminus of Human Herpesvirus 8 Latency-Associated Nuclear Antigen Mediates Dimerization, Transcriptional Repression, and Targeting to Nuclear Bodies
Schwam D, Luciano R, Mahajan S, Wong L, Wilson A. Carboxy Terminus of Human Herpesvirus 8 Latency-Associated Nuclear Antigen Mediates Dimerization, Transcriptional Repression, and Targeting to Nuclear Bodies. Journal Of Virology 2000, 74: 8532-8540. PMID: 10954554, PMCID: PMC116365, DOI: 10.1128/jvi.74.18.8532-8540.2000.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAntigens, ViralCell LineCell NucleusConserved SequenceDimerizationGene Expression Regulation, ViralGenes, ReporterHerpesvirus 8, HumanHumansImmunoblottingLuciferasesMicroscopy, FluorescenceMolecular Sequence DataNuclear ProteinsSequence AlignmentTranscription, GeneticVirionConceptsLatency-associated nuclear antigenC-terminusHeterologous DNA-binding domainDNA-binding domainForms stable dimersPotent transcriptional repressorViral lytic genesC-terminal regionSeries of truncationsHigher-order multimersViral gene expressionNuclear specklesSubnuclear specklesTranscriptional repressionTranscriptional repressorCellular genesCertain B-cell lymphomasNuclear bodiesActive promotersCarboxy terminusGene expressionCell immortalizationFunctional similarityViral episomesIntact proteinN-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the Host Cell Factor-1 binding motif
Luciano R, Wilson A. N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the Host Cell Factor-1 binding motif. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 10757-10762. PMID: 10984507, PMCID: PMC27096, DOI: 10.1073/pnas.190062797.Peer-Reviewed Original ResearchConceptsTranscriptional activation domainHCF-1Activation domainLXXLL motifPotent transcriptional activation domainSequence-specific DNA-binding proteinsN-terminal beta-propeller domainTerminal transcriptional activation domainHost cell factor 1N-terminal 92 amino acidsTranscriptional activator VP16Multiprotein enhancer complexesDNA-binding proteinsProtein-protein interactionsImmediate early gene transcriptionBeta-propeller domainCell factor 1Nuclear hormone receptorsBZIP proteinsEnhancer complexTranscriptional coactivatorGene transcriptionBinding motifLZIPCell cycle