Adverse drug effects across patients with heart failure: a systematic review.
Butzner M, Riello RJ, Sarocco P, Desai N. Adverse drug effects across patients with heart failure: a systematic review. The American Journal Of Managed Care 2022, 28: e113-e120. PMID: 35404555, DOI: 10.37765/ajmc.2022.88844.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyAdverse drug effectsAngiotensin receptor blockersMineralocorticoid receptor antagonistsDrug-related adverse effectsRenal impairmentHeart failureMedical therapyDrug effectsAngiotensin receptor neprilysin inhibitorAdverse effectsReduced ejection fractionAdditional real-world evidenceReal-world evidenceKey search termsSystematic literature reviewReceptor blockersAdult patientsEjection fractionACE inhibitorsReceptor antagonistClinical trialsOvid MEDLINEClinical KeyΒ-blockersWhy has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials
Ahmad T, Miller PE, McCullough M, Desai NR, Riello R, Psotka M, Böhm M, Allen LA, Teerlink JR, Rosano GMC, Lindenfeld J. Why has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials. European Journal Of Heart Failure 2019, 21: 1064-1078. PMID: 31407860, PMCID: PMC6774302, DOI: 10.1002/ejhf.1557.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHeart failureClinical trialsPositive inotropic therapyChronic heart failureReduced ejection fractionAdvanced heart failureCurrent pharmacological therapiesPopulation of patientsDefinitive clinical trialsVentricular assist deviceQuality of lifePositive cardiac inotropeLong-term useInotropic therapyHeart transplantationSurvival benefitCardiac haemodynamicsEjection fractionPharmacological therapyCardiac outputFuture trialsNeurohormonal systemsFunctional statusPositive inotropesPositive inotropy