2024
Efficacy and tolerability of antipsychotic polypharmacy for schizophrenia spectrum disorders. A systematic review and meta-analysis of individual patient data
Lochmann van Bennekom M, IntHout J, Gijsman H, Akdede B, Yağcıoğlu A, Barnes T, Galling B, Gueorguieva R, Kasper S, Kreinin A, Nielsen J, Nielsen R, Remington G, Repo-Tiihonen E, Schmidt-Kraepelin C, Shafti S, Xiao L, Correll C, Verkes R. Efficacy and tolerability of antipsychotic polypharmacy for schizophrenia spectrum disorders. A systematic review and meta-analysis of individual patient data. Schizophrenia Research 2024, 272: 1-11. PMID: 39142215, DOI: 10.1016/j.schres.2024.07.035.Peer-Reviewed Original ResearchClinical Global Impression ScaleSchizophrenia spectrum disordersPositive and Negative Syndrome ScaleBaseline PANSS total scoreAntipsychotic polypharmacyPANSS total scoreTotal scorePositive symptomsPsychotic patientsPositive and Negative Syndrome Scale positive symptom subscaleNegative symptom subscale scoreSubgroup of psychotic patientsBaseline positive symptomsExtrapyramidal side effectsNegative Syndrome ScalePositive symptom subscaleSecond-generation antipsychoticsGlobal Impression ScaleModerators of efficacySeverely psychotic patientsStudy-level moderatorsStudy discontinuationSymptom subscale scoresAntipsychotic monotherapySyndrome ScalePulsed nicotine infusions as a model for smoking: validating a tool to explore nicotine thresholds in humans
Parida S, MacLean R, Gueorguieva R, Sofuoglu M. Pulsed nicotine infusions as a model for smoking: validating a tool to explore nicotine thresholds in humans. Psychopharmacology 2024, 241: 1915-1922. PMID: 38970644, DOI: 10.1007/s00213-024-06609-6.Peer-Reviewed Original ResearchDiscriminative stimulus effectsAddiction thresholdNicotine doseDiscriminative stimulus effects of nicotineStimulus effects of nicotineNicotine deliveryEffects of nicotineOvernight abstinenceStimulus effectsNicotine infusionSubjective effectsTest sessionsNicotineMethodsEleven participantsInfusion procedureLow dosesParticipantsThreshold doseConclusionsTheseAbstinenceDoseHeart rateInfusionSmokingObjectivesToEXAMINING RACIAL DIFFERENCES IN SMOKING-RELATED OUTCOMES IN HUMANS DURING EARLY ABSTINENCE AND AFTER INTRAVENOUS NICOTINE INFUSION
Schwartz E, Palmisano A, Gueorguieva R, DeVito E, Sofuoglu M. EXAMINING RACIAL DIFFERENCES IN SMOKING-RELATED OUTCOMES IN HUMANS DURING EARLY ABSTINENCE AND AFTER INTRAVENOUS NICOTINE INFUSION. Drug And Alcohol Dependence 2024, 260: 110027. DOI: 10.1016/j.drugalcdep.2023.110027.Peer-Reviewed Original ResearchADVANCED CHARACTERIZATION OF ON- ELECTROCARDIOGRAPHIC (ECG) SENSORS’ DISCRIMINATORY POWER IN A HUMAN LABORATORY COCAINE SELF-ADMINISTRATION (SA) PARADIGM
Angarita G, Mayerson T, Pittman B, Nararajan A, Parate A, Marlin B, Gueorguieva R, Potenza M, Ganesan D, Malison R. ADVANCED CHARACTERIZATION OF ON- ELECTROCARDIOGRAPHIC (ECG) SENSORS’ DISCRIMINATORY POWER IN A HUMAN LABORATORY COCAINE SELF-ADMINISTRATION (SA) PARADIGM. Drug And Alcohol Dependence 2024, 260: 110014. DOI: 10.1016/j.drugalcdep.2023.110014.Peer-Reviewed Original ResearchSmartband-based smoking detection and real-time brief mindfulness intervention: findings from a feasibility clinical trial
Horvath M, Pittman B, O’Malley S, Grutman A, Khan N, Gueorguieva R, Brewer J, Garrison K. Smartband-based smoking detection and real-time brief mindfulness intervention: findings from a feasibility clinical trial. Annals Of Medicine 2024, 56: 2352803. PMID: 38823419, PMCID: PMC11146247, DOI: 10.1080/07853890.2024.2352803.Peer-Reviewed Original ResearchConceptsBrief mindfulness interventionsMindfulness exercisesTreatment startersMindfulness interventionSmoking interventionsOnline mindfulness trainingWhite non-HispanicMindfulness trainingTreatment fidelityFeasibility measuresHelpfulness ratingsNon-HispanicDaily smokersPredicting smokingReduce smokingExerciseSmokingCigarette smokingInterventionLow completenessAdherenceParticipantsSmartbandAcceptanceMindfulnessBehavioral Precursors of Nicotine Product Use Trajectories Among Youth
Buta E, Gueorguieva R, Simon P, Garrison K. Behavioral Precursors of Nicotine Product Use Trajectories Among Youth. American Journal Of Preventive Medicine 2024, 67: 360-369. PMID: 38782105, DOI: 10.1016/j.amepre.2024.05.009.Peer-Reviewed Original ResearchNicotine useNicotine productsHarm perceptionsPopulation Assessment of Tobacco and Health StudyBehavioral precursorsPublic health priorityNon-user classPriority intervention targetsPredictors of trajectoriesNonuser classesHealth StudyHealth priorityNicotineHigher oddsCentral network nodesYouth agesNon-usersOddsIntervention targetsPopulation AssessmentYouthPositive expectationsSocioecological factors associated with multiple nicotine product use among U.S. youth: Findings from the population assessment of tobacco and health (PATH) study 2013–2018
Simon P, Stefanovics E, Ying S, Gueorguieva R, Krishnan-Sarin S, Buta E. Socioecological factors associated with multiple nicotine product use among U.S. youth: Findings from the population assessment of tobacco and health (PATH) study 2013–2018. Preventive Medicine 2024, 183: 107956. PMID: 38615947, DOI: 10.1016/j.ypmed.2024.107956.Peer-Reviewed Original ResearchPopulation Assessment of Tobacco and HealthNicotine product useU.S. youthAssociated with tobacco useEstimate adjusted associationsPopulation AssessmentPromote harm reductionTobacco product useMultinomial logistic regressionTobacco useAdjusted associationsSocioecological approachStudy Wave 1Harm reductionProduct useIntrapersonal factorsLogistic regressionWave 1Family factorsLifetime historyNicotine productsOlder ageLifetime usersYouthPrevent escalationAn International, Multidisciplinary Consensus Set of Patient-Centered Outcome Measures for Substance-Related and Addictive Disorders
Black N, Chung S, Tisdale C, Fialho L, Aramrattana A, Assanangkornchai S, Blaszczynski A, Bowden-Jones H, van den Brink W, Brown A, Brown Q, Cottler L, Elsasser M, Ferri M, Florence M, Gueorguieva R, Hampton R, Hudson S, Kelly P, Lintzeris N, Murphy L, Nadkarni A, Neale J, Rosen D, Rumpf H, Rush B, Segal G, Shorter G, Torrens M, Wait C, Young K, Farrell M. An International, Multidisciplinary Consensus Set of Patient-Centered Outcome Measures for Substance-Related and Addictive Disorders. Journal Of Clinical Medicine 2024, 13: 2154. PMID: 38610919, PMCID: PMC11012938, DOI: 10.3390/jcm13072154.Peer-Reviewed Original ResearchInternational Consortium for Health Outcomes MeasurementOutcome measuresEvidence synthesisHealth-related quality of lifeHealth outcome measuresUnited States Institute of MedicineHealth-related qualityInstitute of MedicineModified Delphi processNational outcome measuresMulti-disciplinary working groupConsensus-based recommendationsQuality of lifeTobacco use disorderAddiction treatment servicesEvidence-based proposalSymptom burdenHealthcare settingsMental healthOutcome domainsAddiction expertsDelphi processCase-mixAddictive disordersSubstance-relatedA randomized controlled trial of potential tobacco policies prohibiting menthol flavor in cigarettes and e-cigarettes: a study protocol
Bold K, Sharma A, Haeny A, Gueorguieva R, Buta E, Baldassarri S, Lempert L, Krishnan-Sarin S, O’Malley S. A randomized controlled trial of potential tobacco policies prohibiting menthol flavor in cigarettes and e-cigarettes: a study protocol. BMC Psychiatry 2024, 24: 201. PMID: 38475757, PMCID: PMC10935798, DOI: 10.1186/s12888-024-05619-0.Peer-Reviewed Original ResearchConceptsSmoking menthol cigarettesE-cigarettesCigarette useReduce tobacco-related health disparitiesTobacco-related health disparitiesMenthol cigarettesRates of menthol cigarette useTobacco use statusMenthol cigarette useRandomized controlled trialsPublic health problemHealth disparitiesTobacco policiesFlavored e-cigarettesSmoke-freeMenthol flavorsMenthol policiesBlack adultsQuit smokingNon-Black participantsSmoking behaviorFollow-up visitHealth problemsSecondary outcomesE-cigarette productsLower Dorsal Putamen D2/3 Receptor Availability and Amphetamine-Induced Dopamine Release are Related to Poorer Cognitive Function in Recently Abstinent People Who Smoke and Healthy Controls
Cheung F, Calakos K, Gueorguieva R, Hillmer A, Cosgrove K, Zakiniaeiz Y. Lower Dorsal Putamen D2/3 Receptor Availability and Amphetamine-Induced Dopamine Release are Related to Poorer Cognitive Function in Recently Abstinent People Who Smoke and Healthy Controls. Nicotine & Tobacco Research 2024, 26: 1038-1044. PMID: 38367211, PMCID: PMC11260895, DOI: 10.1093/ntr/ntae031.Peer-Reviewed Original ResearchAmphetamine-induced dopamine releaseBrain-behavior relationshipsAbstinent peopleDorsal striatumCognitive functionDopamine releasePoorer cognitive functionD2/3R availabilityDelayed recallHealthy controlsTests of verbal learningDysregulated dopamine signalingD2/3 receptor availabilityDrug-seeking behaviorDorsolateral prefrontal cortexCogState computerized batteryPositron emission tomography scanAmphetamine administrationMesocortical pathwayMesolimbic pathwayDopamine systemPrefrontal cortexVerbal learningBaseline BPNDDopamine signalingOvervaluation of shape/weight at posttreatment predicts relapse at 12‐month follow‐up after successful behaviorally‐based treatment of binge‐eating disorder
Grilo C, Ivezaj V, Gueorguieva R. Overvaluation of shape/weight at posttreatment predicts relapse at 12‐month follow‐up after successful behaviorally‐based treatment of binge‐eating disorder. International Journal Of Eating Disorders 2024, 57: 1268-1273. PMID: 38321617, PMCID: PMC11093697, DOI: 10.1002/eat.24141.Peer-Reviewed Original ResearchOvervaluation of shape/weightEating-disorder psychopathologyBinge-eating disorderEating Disorder Examination interviewBeck Depression InventoryWeight loss treatmentClinical overvaluationBinge-eating frequencyDiagnostic specifierBinge eatingNon-abstinenceExamination interviewDepression InventoryShape/weightDepression scoresFollow-upPsychopathologyAbstinenceBingeDepressionClinical implicationsDepression 1PosttreatmentDisordersOvervaluationIllusory generalizability of clinical prediction models
Chekroud A, Hawrilenko M, Loho H, Bondar J, Gueorguieva R, Hasan A, Kambeitz J, Corlett P, Koutsouleris N, Krumholz H, Krystal J, Paulus M. Illusory generalizability of clinical prediction models. Science 2024, 383: 164-167. PMID: 38207039, DOI: 10.1126/science.adg8538.Peer-Reviewed Original ResearchThe role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications
Peltier M, Verplaetse T, Altemus M, Zakiniaeiz Y, Ralevski E, Mineur Y, Gueorguieva R, Picciotto M, Cosgrove K, Petrakis I, McKee S. The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications. Frontiers In Neuroendocrinology 2024, 73: 101119. PMID: 38184208, PMCID: PMC11185997, DOI: 10.1016/j.yfrne.2023.101119.Peer-Reviewed Original ResearchPosttraumatic stress disorderAlcohol use disorderStress disorderContext of PTSDPTSD/AUDConcurrent posttraumatic stress disorderUnderlying neurobiological mechanismsUse disordersAlcohol-related variablesNeurobiological mechanismsPTSD diagnosisTreatment developmentTreatment implicationsBody of literatureNovel interventionsClinical literatureRole of neurosteroidsDisordersTreatment outcomesYears of researchAlcohol consumptionExogenous pregnenolonePharmacological treatmentBiological variablesAllopregnanolone
2023
Evidence of subgroup differences in meta‐analyses evaluating medications for alcohol use disorder: An umbrella review
Wallach J, Glick L, Gueorguieva R, O'Malley S. Evidence of subgroup differences in meta‐analyses evaluating medications for alcohol use disorder: An umbrella review. Alcohol Clinical And Experimental Research 2023, 48: 5-15. PMID: 38102794, PMCID: PMC10841726, DOI: 10.1111/acer.15229.Peer-Reviewed Original ResearchEffect of a Personalized Tobacco Treatment Intervention on Smoking Abstinence in Individuals Eligible for Lung Cancer Screening
Cartmel B, Fucito L, Bold K, Neveu S, Li F, Rojewski A, Gueorguieva R, O'Malley S, Herbst R, Toll B. Effect of a Personalized Tobacco Treatment Intervention on Smoking Abstinence in Individuals Eligible for Lung Cancer Screening. Journal Of Thoracic Oncology 2023, 19: 643-649. PMID: 37977486, PMCID: PMC10999350, DOI: 10.1016/j.jtho.2023.11.012.Peer-Reviewed Original ResearchStandard of careLung cancer screeningCancer screeningQuit ratesGain-framed messagingPack-year smoking historySmoking cessation ratesSmoking quit ratesNumber of cigarettesTobacco treatment interventionsYears of ageCessation/reductionChi-square testSelf-reported numberSmoking historyStandard careCessation ratesRandomized trialsTobacco treatmentTobacco cessationBiomarker feedbackLung cancerSmoking abstinencePost randomizationSmoking behaviorRandomized Trial of Mindfulness- and Reappraisal-Based Regulation of Craving Training Among Daily Cigarette Smokers
Roos C, Harp N, Vafaie N, Gueorguieva R, Frankforter T, Carroll K, Kober H. Randomized Trial of Mindfulness- and Reappraisal-Based Regulation of Craving Training Among Daily Cigarette Smokers. Psychology Of Addictive Behaviors 2023, 37: 829-840. PMID: 37535555, PMCID: PMC10834831, DOI: 10.1037/adb0000940.Peer-Reviewed Original ResearchCue-induced cravingDaily cigarette smokersGreater reductionSmoking-related imagesRandomized trialsCigarette smokersDaily smokersQuit ratesSmokingLarge effect sizesIntervention phaseIntervention controlCravingSmokersComputerized interventionSignificant increaseCBTEffect sizeEntire studyInterventionControlPostinterventionROCRegulationTrialsRelationship Between Pain and LGBT Status Among Veterans in Care in a Retrospective Cross-Sectional Cohort
Gordon K, Buta E, Pratt-Chapman M, Brandt C, Gueorguieva R, Warren A, Workman T, Zeng-Treitler Q, Goulet J. Relationship Between Pain and LGBT Status Among Veterans in Care in a Retrospective Cross-Sectional Cohort. Journal Of Pain Research 2023, 16: 4037-4047. PMID: 38054108, PMCID: PMC10695019, DOI: 10.2147/jpr.s432967.Peer-Reviewed Original ResearchRetrospective cross-sectional cohortCross-sectional cohortPersistent painSelf-reported pain scoresVeterans Health AdministrationRobust Poisson modelsCorporate Data WarehouseLGBT veteransPain screeningPain scoresClinic visitsPain assessmentPainAdjusted modelHealth AdministrationGreater painMental healthSubstance useCohortYear of entryBlack veteransHealthcare systemVeteransSignificant differencesAdministrative dataIncluding the term ‘tobacco-free nicotine’ in the nicotine addiction warning label mandated by the US Food and Drug Administration alters risk perceptions and use intentions
Morean M, Gueorguieva R, O'Malley S, Krishnan-Sarin S. Including the term ‘tobacco-free nicotine’ in the nicotine addiction warning label mandated by the US Food and Drug Administration alters risk perceptions and use intentions. Tobacco Control 2023, tc-2023-058133. PMID: 37898544, PMCID: PMC11055938, DOI: 10.1136/tc-2023-058133.Peer-Reviewed Original ResearchWarning labelsParticipant characteristicsUS FoodMultivariable logistic regressionNicotine e-cigarettesPublic health impactAdministration altersMost harmAddictive chemicalNicotine productsNicotine addictionDrug AdministrationAnonymous online surveyE-cigarettesLogistic regressionNicotineYoung individualsVulnerable populationsHealth impactsFDAPublic healthRisk perceptionParticipantsSignificant interactionAddictivenessAssociations Between Childhood Trauma and Tobacco Use Outcomes in Adults after Overnight Abstinence
Palmisano A, Schwartz E, Gueorguieva R, Sofuoglu M. Associations Between Childhood Trauma and Tobacco Use Outcomes in Adults after Overnight Abstinence. Nicotine & Tobacco Research 2023, 26: 324-332. PMID: 37565294, PMCID: PMC10882440, DOI: 10.1093/ntr/ntad135.Peer-Reviewed Original ResearchSevere nicotine dependenceNicotine dependenceCotinine levelsChildhood traumaWithdrawal severityOvernight abstinenceSmoking outcomesAbuse groupHigher plasma cotinine levelsTrauma subscalesPlasma cotinine levelsNegative affectSmoking-related outcomesPublic health interventionsStudies of adultsTobacco use outcomesSevere childhood traumaChildhood trauma historyCessation interventionsMinimal groupsSmoking riskBiochemical assessmentSmoking behaviorSmoking urgesPlasma cortisolDeveloping Researchers with Expertise in Sex as a Biological Variable through SCORE Career Enhancement Core Center Programs
Zakiniaeiz Y, Peltier M, Mineur Y, Gueorguieva R, Picciotto M, Petrakis I, Cosgrove K, McKee S. Developing Researchers with Expertise in Sex as a Biological Variable through SCORE Career Enhancement Core Center Programs. Journal Of Women's Health 2023, 32: 852-857. PMID: 37585509, PMCID: PMC10457604, DOI: 10.1089/jwh.2023.0015.Peer-Reviewed Original Research