2013
Effects of Fructose vs Glucose on Regional Cerebral Blood Flow in Brain Regions Involved With Appetite and Reward Pathways
Page KA, Chan O, Arora J, Belfort-DeAguiar R, Dzuira J, Roehmholdt B, Cline GW, Naik S, Sinha R, Constable RT, Sherwin RS. Effects of Fructose vs Glucose on Regional Cerebral Blood Flow in Brain Regions Involved With Appetite and Reward Pathways. JAMA 2013, 309: 63-70. PMID: 23280226, PMCID: PMC4076145, DOI: 10.1001/jama.2012.116975.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowCerebral blood flowGlucose ingestionFructose ingestionFructose consumptionBlood flowGlucagon-like polypeptide-1Weight gainRegional CBF changesPrevalence of obesityHigh-fructose dietHealthy adult volunteersLower peak levelsConsumption of fructoseMagnetic resonance imaging sessionPosterior cingulate cortexWhole-brain analysisEffects of fructoseFunctional connectivity analysisSatiety hormonesSecondary outcomesDrink ingestionSystemic glucoseVoxel-level analysisInsulin resistance
2001
How does stress increase risk of drug abuse and relapse?
Sinha R. How does stress increase risk of drug abuse and relapse? Psychopharmacology 2001, 158: 343-359. PMID: 11797055, DOI: 10.1007/s002130100917.Peer-Reviewed Original ResearchConceptsDrug abuseSubstance abuseMost major theoriesHuman laboratory studiesField of addictionDrug seekingDrug useTreatment developmentMajor theoriesAbuse altersStress exposureVulnerable individualsHuman researchAbuseAddictsEmpirical evidencePreclinical evidenceClinical observationsRelapseAnimal studiesPreclinical researchSeekingGreater understandingAddictionResearch