Cumulative Adversity Sensitizes Neural Response to Acute Stress: Association with Health Symptoms
Seo D, Tsou KA, Ansell EB, Potenza MN, Sinha R. Cumulative Adversity Sensitizes Neural Response to Acute Stress: Association with Health Symptoms. Neuropsychopharmacology 2013, 39: 670-680. PMID: 24051900, PMCID: PMC3895244, DOI: 10.1038/npp.2013.250.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAnxietyBrainBrain MappingFemaleHeart RateHumansImage Processing, Computer-AssistedImagery, PsychotherapyMagnetic Resonance ImagingMaleOxygenStress, PsychologicalConceptsMedial orbitofrontal cortexAdverse health symptomsStress-induced activityHealth symptomsOrbitofrontal cortexCumulative adversityAcute stressMagnetic resonance imaging resultsAdverse health outcomesNeural responsesCornell Medical IndexFunctional magnetic resonance imaging resultsHigh-Ca groupRight hippocampusRight amygdalaHealthy individualsCA groupHealth outcomesMedical IndexLateral prefrontal cortexSignificant associationSymptomsHealth consequencesPrefrontal cortexTemporal regions