2024
Sex differences in binge drinking-related higher morning cortisol levels and in prospective association with future alcohol intake
McGowan C, Krah M, Fogelman N, Seo D, Sinha R. Sex differences in binge drinking-related higher morning cortisol levels and in prospective association with future alcohol intake. Alcohol And Alcoholism 2024, 59: agae047. PMID: 39053499, DOI: 10.1093/alcalc/agae047.Peer-Reviewed Original ResearchConceptsMorning cortisol levelsCortisol levelsHigher morning cortisol levelsHypothalamic-pituitary-adrenal (HPA) axisSex differencesReports of alcohol consumptionProblematic drinking behaviorAlcohol consumptionAverage cortisol levelsBasal cortisol levelsAlcohol intakeHeavy alcohol useChronic alcohol consumptionHPA axisDrinking behaviorNeuroimaging scansPeripheral cortisolAlcohol useStress systemBinge drinkingMorning cortisolStress hormonesMorning plasma cortisolBingeNon-significant relationshipNeural Correlates of Stress and Alcohol Cue-Induced Alcohol Craving and of Future Heavy Drinking: Evidence of Sex Differences
Radoman M, Fogelman N, Lacadie C, Seo D, Sinha R. Neural Correlates of Stress and Alcohol Cue-Induced Alcohol Craving and of Future Heavy Drinking: Evidence of Sex Differences. American Journal Of Psychiatry 2024, 181: 412-422. PMID: 38706332, PMCID: PMC11117176, DOI: 10.1176/appi.ajp.20230849.Peer-Reviewed Original ResearchConceptsAlcohol use disorderPercentage of heavy drinking daysNeural correlates of stressCue-induced cravingHeavy drinking daysAlcohol cravingSex differencesCorrelates of stressDrinking daysAlcohol cue-induced cravingCue-induced alcohol cravingBed nucleus of the stria terminalisSubgenual anterior cingulate cortexAssessment of alcohol cravingHeavy drinkingAlcohol cue reactivityAssociated with poor treatment outcomesCue-induced responsesNeutral cue exposureAssociated with hypoactivationTreatment-seeking adultsHeavy drinking outcomesEvidence of sex differencesVoxel-based regression analysisAnterior cingulate cortex
2023
Patients with AUD exhibit dampened heart rate variability during sleep as compared to social drinkers
Wemm S, Golden M, Martins J, Fogelman N, Sinha R. Patients with AUD exhibit dampened heart rate variability during sleep as compared to social drinkers. Alcohol And Alcoholism 2023, 58: 653-661. PMID: 37756494, PMCID: PMC10642609, DOI: 10.1093/alcalc/agad061.Peer-Reviewed Original ResearchConceptsAlcohol use disorderHeart rate variabilitySocial drinkersAUD groupChronic heavy alcohol useRate variabilityLife-threatening cardiovascular diseaseHRV measuresPatient-related symptomsPatient-reported symptomsHF/LF ratioSevere alcohol use disorderNervous system processesHeavy alcohol useParasympathetic dysfunctionCardiovascular diseaseHeart rate monitoringObservational studySleep difficultiesHeart rateParasympathetic activationUse disordersRSA amplitudeCardiovascular systemDays of monitoringTherapeutics for Substance-Using Women: The Need to Elucidate Sex-Specific Targets for Better-Tailored Treatments
Fox H, Milivojevic V, Sinha R. Therapeutics for Substance-Using Women: The Need to Elucidate Sex-Specific Targets for Better-Tailored Treatments. Handbook Of Experimental Pharmacology 2023, 282: 127-161. PMID: 37592081, DOI: 10.1007/164_2023_687.Peer-Reviewed Original ResearchConceptsSubstance-using womenExogenous progesteroneBetter tailor treatmentsStress-induced cravingFace of stressSex-specific targetsGender-related differencesAdrenergic medicationsStress-related adaptationClinical trialsSpecific treatmentMedication developmentAlcohol consumptionCompulsive drugBiobehavioral mechanismsDrinking historyMedical problemsInnovative medicationsMedicationsNovel targetWomenGuanfacineProgesteroneTreatmentEfficacyBrain volumes in alcohol use disorder: Do females and males differ? A whole‐brain magnetic resonance imaging mega‐analysis
Maggioni E, Rossetti M, Allen N, Batalla A, Bellani M, Chye Y, Cousijn J, Goudriaan A, Hester R, Hutchison K, Li C, Martin‐Santos R, Momenan R, Sinha R, Schmaal L, Solowij N, Suo C, van Holst R, Veltman D, Yücel M, Thompson P, Conrod P, Mackey S, Garavan H, Brambilla P, Lorenzetti V. Brain volumes in alcohol use disorder: Do females and males differ? A whole‐brain magnetic resonance imaging mega‐analysis. Human Brain Mapping 2023, 44: 4652-4666. PMID: 37436103, PMCID: PMC10400785, DOI: 10.1002/hbm.26404.Peer-Reviewed Original ResearchMifepristone as a pharmacological intervention for stress‐induced alcohol craving: A human laboratory study
Haass‐Koffler C, Magill M, Cannella N, Brown J, Aoun E, Cioe P, Sinha R, Swift R, Ciccocioppo R, Leggio L. Mifepristone as a pharmacological intervention for stress‐induced alcohol craving: A human laboratory study. Addiction Biology 2023, 28: e13288. PMID: 37369125, PMCID: PMC10313137, DOI: 10.1111/adb.13288.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DrinkingAlcoholismCravingDouble-Blind MethodEthanolHumansHydrocortisoneMifepristoneConceptsAlcohol use disorderHuman laboratory studiesAdverse eventsAlcohol pharmacokineticsAlcohol cravingSubjective effectsSafety of mifepristonePlacebo-controlled trialStress-induced alcoholLack of effectCue-reactivity procedureBlood pressurePhase 1/2Alcohol drinkingGeneralized Estimating EquationsYohimbine administrationHemodynamic parametersPharmacological interventionsSaliva outputDay administrationUse disordersMifepristoneNon-treatment seekersAlcohol consumptionPlacebo conditionHypothalamic‐pituitary‐adrenal and autonomic response to psychological stress in abstinent alcohol use disorder individuals with and without depressive symptomatology
Syed S, Sinha R, Milivojevic V, MacDougall A, LaValle H, Angarita G, Fox H. Hypothalamic‐pituitary‐adrenal and autonomic response to psychological stress in abstinent alcohol use disorder individuals with and without depressive symptomatology. Human Psychopharmacology Clinical And Experimental 2023, 38: e2867. PMID: 37165544, DOI: 10.1002/hup.2867.Peer-Reviewed Original ResearchConceptsAlcohol use disorderRelapse riskDepressive symptomatologyDepressive symptomsAutonomic responsesIndividual relapse riskChronic alcohol useDepressive pathophysiologyAdrenocorticotropic hormoneInhibitory systemPlasma measuresUse disordersClinical practicePhasic changesConsecutive daysAlcohol usePsychological stressStroop performanceDisorder individualsDrinking controlsSymptomatologyImagery exposureCounterbalanced orderSymptomsDepression
2022
Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder
Milivojevic V, Sullivan L, Tiber J, Fogelman N, Simpson C, Hermes G, Sinha R. Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder. Psychopharmacology 2022, 240: 101-114. PMID: 36445398, PMCID: PMC10630889, DOI: 10.1007/s00213-022-06278-3.Peer-Reviewed Original ResearchConceptsAlcohol use disorderDiastolic blood pressureHeart rateGABAergic transmissionNeuroactive steroidsHPA axisRelapse riskUse disordersAlcohol cravingTreatment of AUDAlcohol cue-induced cravingPilot clinical trialStress-induced anxietyCue-induced cravingAutonomic arousalNeurosteroid systemPreg groupStudy drugDBP responseBlood pressureDay groupClinical trialsPregnenolone levelsWeek 2Cue-provoked cravingAlcohol’s Negative Emotional Side: The Role of Stress Neurobiology in Alcohol Use Disorder
Sinha R. Alcohol’s Negative Emotional Side: The Role of Stress Neurobiology in Alcohol Use Disorder. Alcohol Research 2022, 42: 12. PMID: 36338609, PMCID: PMC9621746, DOI: 10.35946/arcr.v42.1.12.Peer-Reviewed Original ResearchConceptsAlcohol use disorderUse disordersNational InstituteEvidence-based diagnosisIntramural Research ProgramAlcohol researchAlcohol-related problemsAlcohol abuseClinical researchMental healthTreatment researchStress neurobiologyDiagnosisPreventionDisordersNIAAAPresentationHealthAlcoholismInstitute
1999
Naturalistic Follow-Up of Drinking Behavior Following Participation in an Alcohol Administration Study
Sinha R, Krishnan-Sarin S, Farren C, O'Malley S. Naturalistic Follow-Up of Drinking Behavior Following Participation in an Alcohol Administration Study. Journal Of Substance Use And Addiction Treatment 1999, 17: 159-162. PMID: 10435264, DOI: 10.1016/s0740-5472(98)00058-0.Peer-Reviewed Original ResearchConceptsAlcohol administration researchAlcohol-dependent individualsSubsequent drinkingDrinking behaviorBrief motivational interventionAlcohol administration studyParticipants' drinking behaviorMotivational interventionIndividual motivationNumber of drinksAssessment of drinkingAdministration of alcoholAdministration researchSelf-administration studiesDrinking daysEffects of naltrexoneAlcohol dependenceParticipantsMotivationDrinkingIndividualsClinical benefitFollow-upBaseline levelsClinical need
1993
Simple Reaction Time Event‐Related Potentials: Effects of Alcohol and Sleep Deprivation
Krull K, Smith L, Sinha R, Parsons O. Simple Reaction Time Event‐Related Potentials: Effects of Alcohol and Sleep Deprivation. Alcohol Clinical And Experimental Research 1993, 17: 771-777. PMID: 8214412, DOI: 10.1111/j.1530-0277.1993.tb00839.x.Peer-Reviewed Original ResearchConceptsBreath alcohol concentrationSleep deprivationNormal male subjectsEvent-related potentialsLatency of N2Effects of alcoholVisual event-related potentialsMale subjectsAlcohol intoxicationSimple reaction timeResponse activationStimulus detectionDeprivationAlcohol concentrationNegative componentTreatmentAdditive increaseElectrophysiological indices predict resumption of drinking in sober alcoholics
Glenn S, Sinha R, Parsons O. Electrophysiological indices predict resumption of drinking in sober alcoholics. Alcohol 1993, 10: 89-95. PMID: 8442897, DOI: 10.1016/0741-8329(93)90086-4.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAdultAlcohol DrinkingAlcoholismBrainElectrophysiologyFemaleHumansMaleMiddle AgedMultivariate AnalysisRecurrenceConceptsInpatient alcoholism treatment programResumption of drinkingInitial testing sessionAlcoholism treatment programSocial predictor variablesChronic alcoholicsEvent-related potentialsMultivariate analysisSober alcoholicsTreatment programNonalcoholic controlsDrinking patternsN200 latencyAlcoholicsChi 2Biopsychosocial modelP300 amplitudeTesting sessionsStimulus taskElectrophysiological indices
1989
Drinking variables, affective measures and neuropsychological performance: Familial alcoholism and gender correlates
Sinha R, Parsons O, Glenn S. Drinking variables, affective measures and neuropsychological performance: Familial alcoholism and gender correlates. Alcohol 1989, 6: 77-85. PMID: 2719819, DOI: 10.1016/0741-8329(89)90077-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingAlcoholismCognitionEmotionsFemaleHumansLearningMaleMemoryPerceptionPsychomotor PerformanceSex FactorsConceptsDrinking variablesNeuropsychological performance scoresFamily history-negative (FH-) alcoholicsNeuropsychological test performanceAlcohol intake measuresCognitive functioningNeuropsychological measuresAlcohol consumption variablesAffective measuresFemale alcoholicsNeuropsychological performanceTest performanceDepression Inventory scoresAffective symptomatologyAnxiety scoresBeck Depression Inventory scoresImpairment IndexFamilial alcoholismInventory scoresPerformance scoresIntake measuresMeasuresSignificant relationshipGender correlatesAlcohol consumption