2021
This is Your Brain in Meltdown
Arnsten A, Mazure CM, Sinha R. This is Your Brain in Meltdown. Scientific American 2021, 306: 48-53. PMID: 22486116, PMCID: PMC4774859, DOI: 10.1038/scientificamerican0412-48.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal GlandsBrainFemaleHumansHydrocortisoneMaleNeurotransmitter AgentsPrefrontal CortexPyramidal CellsSex FactorsStress, Psychological
2008
Chronic Stress, Drug Use, and Vulnerability to Addiction
Sinha R. Chronic Stress, Drug Use, and Vulnerability to Addiction. Annals Of The New York Academy Of Sciences 2008, 1141: 105-130. PMID: 18991954, PMCID: PMC2732004, DOI: 10.1196/annals.1441.030.Peer-Reviewed Original ResearchMeSH KeywordsArousalChronic DiseaseCorticotropin-Releasing HormoneDisease SusceptibilityEmotionsFemaleHumansHypothalamo-Hypophyseal SystemIllicit DrugsLimbic SystemMaleNeurotransmitter AgentsPituitary-Adrenal SystemRewardSelf MedicationStress, PhysiologicalStress, PsychologicalSubstance Withdrawal SyndromeSubstance-Related DisordersSympathetic Nervous SystemConceptsCompulsive drug seekingStress-related riskDevelopment of addictionChronic drug useEarly life stressMotivational systemsIndividual-level variablesRelapse susceptibilityRelapse vulnerabilityDrug seekingAutonomic arousalDrug useLife stressDrug-experienced animalsSpecific stressorsChild maltreatmentSubstance useMesolimbic dopamineStress exposureStress regulationAddictionChronic stressCentral noradrenergic systemNoradrenergic systemButyric acid pathway