2022
Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder
Milivojevic V, Charron L, Fogelman N, Hermes G, Sinha R. Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder. Biomolecules 2022, 12: 1593. PMID: 36358943, PMCID: PMC9687893, DOI: 10.3390/biom12111593.Peer-Reviewed Original ResearchConceptsDiastolic blood pressureCocaine use disorderHeart ratePrecursor pregnenoloneUse disordersCocaine cravingCue-induced cocaine cravingCue-induced anxietyWeeks of treatmentCue-induced cravingAutonomic arousalChronic cocaine usePreg groupBlood pressureDay groupRelapse riskHigher cocainePregnenolone levelsCue-provoked cravingSeparate daysAutonomic responsesCocaine useTreatment-seeking individualsCravingSteroid systems
1994
Effects of ethanol on the acoustic startle reflex in humans
Grillon C, Sinha R, O'Malley S. Effects of ethanol on the acoustic startle reflex in humans. Psychopharmacology 1994, 114: 167-171. PMID: 7846199, DOI: 10.1007/bf02245459.Peer-Reviewed Original ResearchConceptsEffects of ethanolStartle responsePrepulse inhibitionPrepulse stimulusStartle reflexHealthy normal subjectsAcoustic startle reflexAcoustic startle responseAcute ethanolSensorimotor reactivityNormal subjectsStartle amplitudeStartle reactivitySeparate daysReflex experimentsReflexStartle probesInhibitionStimuliPlaceboResponse