2018
Central and Peripheral Biomarkers of Stress Response for Addiction Risk and Relapse Vulnerability
Milivojevic V, Sinha R. Central and Peripheral Biomarkers of Stress Response for Addiction Risk and Relapse Vulnerability. Trends In Molecular Medicine 2018, 24: 173-186. PMID: 29396148, PMCID: PMC6511993, DOI: 10.1016/j.molmed.2017.12.010.Peer-Reviewed Original ResearchConceptsSubstance use disordersTreatment of SUDsDevelopment of SUDHigh relapse rateFunctional brain alterationsCentral stress responseAdrenal axis markersStress response measuresRelapse ratePeripheral biomarkersClinical symptomatologyBrain alterationsUse disordersCandidate biomarkersAutonomic responsesRelapse vulnerabilityPutative biomarkersAddiction riskStress responseBiomarkersTreatmentResponsePathophysiologySymptomatologyPrevention
2008
Chronic Stress, Drug Use, and Vulnerability to Addiction
Sinha R. Chronic Stress, Drug Use, and Vulnerability to Addiction. Annals Of The New York Academy Of Sciences 2008, 1141: 105-130. PMID: 18991954, PMCID: PMC2732004, DOI: 10.1196/annals.1441.030.Peer-Reviewed Original ResearchMeSH KeywordsArousalChronic DiseaseCorticotropin-Releasing HormoneDisease SusceptibilityEmotionsFemaleHumansHypothalamo-Hypophyseal SystemIllicit DrugsLimbic SystemMaleNeurotransmitter AgentsPituitary-Adrenal SystemRewardSelf MedicationStress, PhysiologicalStress, PsychologicalSubstance Withdrawal SyndromeSubstance-Related DisordersSympathetic Nervous SystemConceptsCompulsive drug seekingStress-related riskDevelopment of addictionChronic drug useEarly life stressMotivational systemsIndividual-level variablesRelapse susceptibilityRelapse vulnerabilityDrug seekingAutonomic arousalDrug useLife stressDrug-experienced animalsSpecific stressorsChild maltreatmentSubstance useMesolimbic dopamineStress exposureStress regulationAddictionChronic stressCentral noradrenergic systemNoradrenergic systemButyric acid pathway