2023
Blunted neural reward response to alcohol and greater alcohol motivation in binge drinkers in a randomized clinical experiment
Blaine S, Fogelman N, Lacadie C, Constable T, Sinha R. Blunted neural reward response to alcohol and greater alcohol motivation in binge drinkers in a randomized clinical experiment. Alcohol Clinical And Experimental Research 2023, 47: 1067-1078. PMID: 37070596, PMCID: PMC10289130, DOI: 10.1111/acer.15082.Peer-Reviewed Original ResearchAlcohol taste testFunctional magnetic resonance imagingAlcohol motivationSupplementary motor areaOrbitofrontal cortexInferior frontal gyrus regionsPerfusion functional magnetic resonance imagingEnhanced neural responseNeural reward responsesMedial orbitofrontal cortexPlacebo sessionAlcohol use disorderBrain reward regionsPlacebo-controlled effectsNeural processesOFC responsesReward responsesNeural responsesPlacebo beerSocial drinkersCerebral blood flowReward regionsBD relativeVentral striatumAlcohol effects
2013
Cumulative Adversity Sensitizes Neural Response to Acute Stress: Association with Health Symptoms
Seo D, Tsou KA, Ansell EB, Potenza MN, Sinha R. Cumulative Adversity Sensitizes Neural Response to Acute Stress: Association with Health Symptoms. Neuropsychopharmacology 2013, 39: 670-680. PMID: 24051900, PMCID: PMC3895244, DOI: 10.1038/npp.2013.250.Peer-Reviewed Original ResearchConceptsMedial orbitofrontal cortexAdverse health symptomsStress-induced activityHealth symptomsOrbitofrontal cortexCumulative adversityAcute stressMagnetic resonance imaging resultsAdverse health outcomesNeural responsesCornell Medical IndexFunctional magnetic resonance imaging resultsHigh-Ca groupRight hippocampusRight amygdalaHealthy individualsCA groupHealth outcomesMedical IndexLateral prefrontal cortexSignificant associationSymptomsHealth consequencesPrefrontal cortexTemporal regions
2012
Cumulative Adversity and Smaller Gray Matter Volume in Medial Prefrontal, Anterior Cingulate, and Insula Regions
Ansell EB, Rando K, Tuit K, Guarnaccia J, Sinha R. Cumulative Adversity and Smaller Gray Matter Volume in Medial Prefrontal, Anterior Cingulate, and Insula Regions. Biological Psychiatry 2012, 72: 57-64. PMID: 22218286, PMCID: PMC3391585, DOI: 10.1016/j.biopsych.2011.11.022.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexGray matter volumeCumulative adversityPrefrontal cortexLife eventsSmaller gray matter volumeAnterior cingulateMatter volumeCingulate regionsRecent stressful life eventsCommunity participantsHealthy community participantsCumulative life eventsStressful life eventsStress-related psychopathologyAdverse life eventsAnterior cingulate regionsChronic stress effectsInsula regionsLife traumaKey prefrontalMedial prefrontalCommunity sampleOrbitofrontal cortexRight insula