2023
Chronic pain, chronic stress and substance use: overlapping mechanisms and implications
Schaffer J, Fogelman N, Seo D, Sinha R. Chronic pain, chronic stress and substance use: overlapping mechanisms and implications. Frontiers In Pain Research 2023, 4: 1145934. PMID: 37415830, PMCID: PMC10320206, DOI: 10.3389/fpain.2023.1145934.Peer-Reviewed Original ResearchChronic painChronic stressSubstance useSubstance misuseCommon reasons adultsCommon pathophysiologic processChronic pain pathologiesMedial prefrontal circuitsPrefrontal cortex dysfunctionPrescription opioidsPain pathologiesPathophysiologic processesPainBrain areasBiologic underpinningsMedical careReasons adultsEnormous burdenNeural circuitryPrefrontal circuitsVentromedial prefrontal cortex dysfunctionPsychobiological processesIndividual wellnessWellnessRisk
2019
How Spirituality May Mitigate Against Stress and Related Mental Disorders: a Review and Preliminary Neurobiological Evidence
McClintock C, Worhunsky P, Balodis I, Sinha R, Miller L, Potenza M. How Spirituality May Mitigate Against Stress and Related Mental Disorders: a Review and Preliminary Neurobiological Evidence. Current Behavioral Neuroscience Reports 2019, 6: 253-262. DOI: 10.1007/s40473-019-00195-0.Peer-Reviewed Original ResearchBrain mechanismsStress processingSelf-referential processingFunctional magnetic resonance imaging (fMRI) dataPotential brain mechanismsSpecific brain mechanismsImportant resilience factorMental disordersPreliminary fMRI dataStress-related psychopathologyMechanisms of psychopathologyDefault mode networkStress-related mental disordersCognitive processingNeurobiological evidenceNeural mechanismsNeural responsesNeuroscientific researchResilience factorsMagnetic resonance imaging dataNeural circuitryFMRI dataStress responsivityBrain regionsAcute stress
2007
Co-Occurring Mental and Substance Use Disorders: The Neurobiological Effects of Chronic Stress
Brady K, Sinha R. Co-Occurring Mental and Substance Use Disorders: The Neurobiological Effects of Chronic Stress. FOCUS The Journal Of Lifelong Learning In Psychiatry 2007, 5: 229-239. DOI: 10.1176/foc.5.2.foc229.Peer-Reviewed Original ResearchSubstance use disordersUse disordersPsychiatric disordersCo-Occurring MentalCo-occurring disordersAttention deficit hyperactivity disorderArea of comorbidityPosttraumatic stress disorderPopulation of peopleDeficit hyperactivity disorderNeurotransmitter systemsMood disordersNeurobiological effectsMental illnessDiagnostic groupsChronic stressNeurobiological interfaceNeural circuitryStress disorderHyperactivity disorderDisordersHigh rateComorbiditiesTechnical advancesIllness