2024
Substance use patterns, quantities, and associated risk factors in women with polysubstance misuse
Fogelman N, Tate M, Wemm S, Sullivan L, Hart R, Vacey E, Fox H, Sinha R. Substance use patterns, quantities, and associated risk factors in women with polysubstance misuse. Addiction Biology 2024, 29: 10.1111/adb.13390. PMID: 38619491, PMCID: PMC11017971, DOI: 10.1111/adb.13390.Peer-Reviewed Original ResearchConceptsPolysubstance useDepressive symptomsSubstance use patternsDrug cravingRisk factorsPatterns of polysubstance useSingle substance useAssociated with polysubstance usePlacebo-controlled studyHigher cravingGuanfacine treatmentCross-sectional observational studyPolysubstance use patternsCraving managementLife eventsCravingPolysubstance misuseSubstance useOpioid amountsPain ratingsStress/traumaObservational studyAnxietyPainPolysubstance
2023
Cumulative adversity and emotion dysregulation effects on suicidal ideation and attempts in a community sample
Tate M, Sinha R, Wemm S. Cumulative adversity and emotion dysregulation effects on suicidal ideation and attempts in a community sample. Journal Of Psychiatric Research 2023, 170: 277-282. PMID: 38183699, DOI: 10.1016/j.jpsychires.2023.12.029.Peer-Reviewed Original ResearchEmotion dysregulationCumulative adversityCommunity adultsLifetime traumaLife eventsSuicidal ideationNonacceptance of emotionsHigher emotion dysregulationSuicide attemptsHighest cumulative stressMajor life eventsConcurrent suicidal ideationRecent life eventsTraumatic eventsDifficult emotionsEmotional responsesLife traumaCommunity sampleTrauma historyAdversityChronic stressorsNonacceptanceSuicidal thoughtsCumulative stressEmotionsGreater stress and trauma mediate race-related differences in epigenetic age between Black and White young adults in a community sample
Holloway T, Harvanek Z, Xu K, Gordon D, Sinha R. Greater stress and trauma mediate race-related differences in epigenetic age between Black and White young adults in a community sample. Neurobiology Of Stress 2023, 26: 100557. PMID: 37501940, PMCID: PMC10369475, DOI: 10.1016/j.ynstr.2023.100557.Peer-Reviewed Original ResearchTraumatic eventsGrimAge accelerationMore traumatic eventsWhite participantsExploratory mediation analysisMajor life eventsImpact of stressAssaultive traumaPsychological dataCross-sectional sampleCommunity sampleLife eventsMediation analysisLifetime stressRace-related differencesChronic stressorsCumulative stressorsYoung adultsCumulative stressChronic illnessYoung adult populationStressorsGreater stressHealthy adultsParticipantsRegular cannabis use is associated with history of childhood and lifetime trauma in a non-clinical community sample
Bassir Nia A, Weleff J, Fogelman N, Nourbakhsh S, Sinha R. Regular cannabis use is associated with history of childhood and lifetime trauma in a non-clinical community sample. Journal Of Psychiatric Research 2023, 159: 159-164. PMID: 36736285, PMCID: PMC10024801, DOI: 10.1016/j.jpsychires.2023.01.036.Peer-Reviewed Original ResearchConceptsMajor life eventsChildhood traumaLife eventsChildhood Trauma QuestionnaireLifetime traumaCannabis useNon-clinical community sampleChronic stressNeurobiology of stressRegular cannabis useGender differencesRegular useSelf-report questionnairesRecent life eventsPotential gender differencesCross-sectional studyUrine drug testingLife traumaLogistic regression analysisAdversity indexCommunity sampleCannabis usersTrauma QuestionnaireHigh rateSubstance use
2017
2341
Vaughan C, Stangl B, Sinha R, Ramchandani V. 2341. Journal Of Clinical And Translational Science 2017, 1: 36-36. PMCID: PMC6798883, DOI: 10.1017/cts.2017.132.Peer-Reviewed Original ResearchChronic stressful eventsDrug Effects QuestionnaireNon-dependent drinkersAlcohol Urge QuestionnaireStress interviewStressful eventsChronic stressorsEarly life stress eventsBetter treatment outcomesChronic stress scoresAlcohol use disorderEarly life stressImpact of stressLife eventsRecent life eventsLife stress eventsImpaired Control ScaleMore chronic stressorsAlcohol infusionIntravenous alcoholTreatment outcomesPriming exposureLife Stress QuestionnaireUse disordersEffects Questionnaire
2013
The Effects of Stress on Physical Activity and Exercise
Stults-Kolehmainen MA, Sinha R. The Effects of Stress on Physical Activity and Exercise. Sports Medicine 2013, 44: 81-121. PMID: 24030837, PMCID: PMC3894304, DOI: 10.1007/s40279-013-0090-5.Peer-Reviewed Original ResearchConceptsInfluence of stressWork-family conflictFace of stressLifetime cumulative adversityStress-related reductionLevel of stressStages of changeHuman participantsIndicators of PAPerceived stressEffects of stressCumulative adversityLife eventsRole strainJob strainExercise adoptionTheoretical orientationOlder adultsPsychological stressSubjective measuresPreliminary evidencePhysical activityStudies of exercisePA relationshipHigh-quality prospective research
2012
Cumulative Adversity and Smaller Gray Matter Volume in Medial Prefrontal, Anterior Cingulate, and Insula Regions
Ansell EB, Rando K, Tuit K, Guarnaccia J, Sinha R. Cumulative Adversity and Smaller Gray Matter Volume in Medial Prefrontal, Anterior Cingulate, and Insula Regions. Biological Psychiatry 2012, 72: 57-64. PMID: 22218286, PMCID: PMC3391585, DOI: 10.1016/j.biopsych.2011.11.022.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexGray matter volumeCumulative adversityPrefrontal cortexLife eventsSmaller gray matter volumeAnterior cingulateMatter volumeCingulate regionsRecent stressful life eventsCommunity participantsHealthy community participantsCumulative life eventsStressful life eventsStress-related psychopathologyAdverse life eventsAnterior cingulate regionsChronic stress effectsInsula regionsLife traumaKey prefrontalMedial prefrontalCommunity sampleOrbitofrontal cortexRight insula