2019
Differential resting state connectivity responses to glycemic state in type 1 diabetes
Parikh L, Seo D, Lacadie C, Belfort-DeAguiar R, Groskreutz D, Hamza M, Dai F, Scheinost D, Sinha R, Constable R, Sherwin R, Hwang J. Differential resting state connectivity responses to glycemic state in type 1 diabetes. The Journal Of Clinical Endocrinology & Metabolism 2019 DOI: 10.1210/jcem/dgz004.Peer-Reviewed Original ResearchType 1 diabetesState functional connectivityHealthy controlsDefault mode networkFunctional connectivityImpact of T1DMHealthy control volunteersAcademic medical centerAngular gyrus connectivityState connectivity patternsFunctional connectivity analysisHyperinsulinemic euglycemicHypoglycemic unawarenessHypoglycemia unawarenessHypoglycemic clampHypoglycemia awarenessFunctional outcomeControl volunteersMild hypoglycemiaGlycemic stateObservational studyMedical CenterT1DMHypoglycemiaNeurocognitive consequences
2013
Effects of Fructose vs Glucose on Regional Cerebral Blood Flow in Brain Regions Involved With Appetite and Reward Pathways
Page KA, Chan O, Arora J, Belfort-DeAguiar R, Dzuira J, Roehmholdt B, Cline GW, Naik S, Sinha R, Constable RT, Sherwin RS. Effects of Fructose vs Glucose on Regional Cerebral Blood Flow in Brain Regions Involved With Appetite and Reward Pathways. JAMA 2013, 309: 63-70. PMID: 23280226, PMCID: PMC4076145, DOI: 10.1001/jama.2012.116975.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowCerebral blood flowGlucose ingestionFructose ingestionFructose consumptionBlood flowGlucagon-like polypeptide-1Weight gainRegional CBF changesPrevalence of obesityHigh-fructose dietHealthy adult volunteersLower peak levelsConsumption of fructoseMagnetic resonance imaging sessionPosterior cingulate cortexWhole-brain analysisEffects of fructoseFunctional connectivity analysisSatiety hormonesSecondary outcomesDrink ingestionSystemic glucoseVoxel-level analysisInsulin resistance