2024
Childhood adversity, accelerated GrimAge, and associated health consequences
Harvanek Z, Kudinova A, Wong S, Xu K, Brick L, Daniels T, Marsit C, Burt A, Sinha R, Tyrka A. Childhood adversity, accelerated GrimAge, and associated health consequences. Journal Of Behavioral Medicine 2024, 47: 913-926. PMID: 38762606, PMCID: PMC11365810, DOI: 10.1007/s10865-024-00496-0.Peer-Reviewed Original ResearchBody mass indexChildhood Trauma QuestionnaireGrimAge accelerationEarly life stressChildhood adversityAssociated with higher body mass indexCross-sectional cohort of adultsMetabolic healthEffect of body mass indexHigher body mass indexPhysical health problemsLife stressCohort of adultsAssociated health consequencesEffects of early life stressMetabolic health effectsModerating effect of body mass indexChildhood Trauma Questionnaire subscalesCross-sectional cohortCardiometabolic healthAccelerated GrimAgeCardiometabolic diseasesMedical illnessHealth consequencesMass index
2018
Stress and Addiction
Sinha R. Stress and Addiction. 2018, 299-311. DOI: 10.4324/9781315689197-25.Peer-Reviewed Original ResearchExecutive control functionsNegative emotional statesChronic stressEarly life stressCortical brain regionsEmotional statesAddiction vulnerabilityStressful situationsMesolimbic dopamine pathwayLife stressAddiction severityBrain regionsType of adaptationDrug useDopamine pathwayAlters activityRelapse riskEmotionsIndividualsDistressControl functionsAddictionAbuseBehaviorStress
2017
2341
Vaughan C, Stangl B, Sinha R, Ramchandani V. 2341. Journal Of Clinical And Translational Science 2017, 1: 36-36. PMCID: PMC6798883, DOI: 10.1017/cts.2017.132.Peer-Reviewed Original ResearchChronic stressful eventsDrug Effects QuestionnaireNon-dependent drinkersAlcohol Urge QuestionnaireStress interviewStressful eventsChronic stressorsEarly life stress eventsBetter treatment outcomesChronic stress scoresAlcohol use disorderEarly life stressImpact of stressLife eventsRecent life eventsLife stress eventsImpaired Control ScaleMore chronic stressorsAlcohol infusionIntravenous alcoholTreatment outcomesPriming exposureLife Stress QuestionnaireUse disordersEffects Questionnaire
2008
Chronic Stress, Drug Use, and Vulnerability to Addiction
Sinha R. Chronic Stress, Drug Use, and Vulnerability to Addiction. Annals Of The New York Academy Of Sciences 2008, 1141: 105-130. PMID: 18991954, PMCID: PMC2732004, DOI: 10.1196/annals.1441.030.Peer-Reviewed Original ResearchMeSH KeywordsArousalChronic DiseaseCorticotropin-Releasing HormoneDisease SusceptibilityEmotionsFemaleHumansHypothalamo-Hypophyseal SystemIllicit DrugsLimbic SystemMaleNeurotransmitter AgentsPituitary-Adrenal SystemRewardSelf MedicationStress, PhysiologicalStress, PsychologicalSubstance Withdrawal SyndromeSubstance-Related DisordersSympathetic Nervous SystemConceptsCompulsive drug seekingStress-related riskDevelopment of addictionChronic drug useEarly life stressMotivational systemsIndividual-level variablesRelapse susceptibilityRelapse vulnerabilityDrug seekingAutonomic arousalDrug useLife stressDrug-experienced animalsSpecific stressorsChild maltreatmentSubstance useMesolimbic dopamineStress exposureStress regulationAddictionChronic stressCentral noradrenergic systemNoradrenergic systemButyric acid pathway