2010
Cocaine
Beech R, Sinha R. Cocaine. 2010, 397-416. DOI: 10.1007/978-1-4419-0338-9_18.Peer-Reviewed Original ResearchCognitive behavior therapyBehavior therapyCocaine dependenceGeneral cognitive behavior therapyContingency managementRelapse prevention techniquesCompulsive drug seekingReward-related informationContingency management techniquesCocaine-taking behaviorConditions of challengeExecutive controlLong-term neuroadaptationsCocaine-related disordersDrug seekingCocaine useAdditional clinical attentionExtended abstinenceAnxiety disordersNeurobiological aspectsChronic cocaine useRegular cocaine useRelapse preventionPsychological symptomsNegative consequences
2008
Chronic Stress, Drug Use, and Vulnerability to Addiction
Sinha R. Chronic Stress, Drug Use, and Vulnerability to Addiction. Annals Of The New York Academy Of Sciences 2008, 1141: 105-130. PMID: 18991954, PMCID: PMC2732004, DOI: 10.1196/annals.1441.030.Peer-Reviewed Original ResearchMeSH KeywordsArousalChronic DiseaseCorticotropin-Releasing HormoneDisease SusceptibilityEmotionsFemaleHumansHypothalamo-Hypophyseal SystemIllicit DrugsLimbic SystemMaleNeurotransmitter AgentsPituitary-Adrenal SystemRewardSelf MedicationStress, PhysiologicalStress, PsychologicalSubstance Withdrawal SyndromeSubstance-Related DisordersSympathetic Nervous SystemConceptsCompulsive drug seekingStress-related riskDevelopment of addictionChronic drug useEarly life stressMotivational systemsIndividual-level variablesRelapse susceptibilityRelapse vulnerabilityDrug seekingAutonomic arousalDrug useLife stressDrug-experienced animalsSpecific stressorsChild maltreatmentSubstance useMesolimbic dopamineStress exposureStress regulationAddictionChronic stressCentral noradrenergic systemNoradrenergic systemButyric acid pathway
2007
Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal–limbic dysfunction in psycho-stimulant addiction
Li CS, Sinha R. Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal–limbic dysfunction in psycho-stimulant addiction. Neuroscience & Biobehavioral Reviews 2007, 32: 581-597. PMID: 18164058, PMCID: PMC2263143, DOI: 10.1016/j.neubiorev.2007.10.003.Peer-Reviewed Original ResearchConceptsInhibitory controlPrefrontal activityDrug seekingHabitual drug seekingCognitive inhibitory controlCompulsive drug seekingVentromedial prefrontal regionsFrontal-limbic dysfunctionStress-related cravingAnterior cingulate cortexStress regulationPsychological processesNeural underpinningsSalient stimuliStress processingPrefrontal regionsComponent processesStriatal responsesDrug use behaviorsCingulate cortexNeural systemsPsychostimulant dependenceUse behaviorsNeural pathwaysAddiction