2022
Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder
Milivojevic V, Charron L, Fogelman N, Hermes G, Sinha R. Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder. Biomolecules 2022, 12: 1593. PMID: 36358943, PMCID: PMC9687893, DOI: 10.3390/biom12111593.Peer-Reviewed Original ResearchConceptsDiastolic blood pressureCocaine use disorderHeart ratePrecursor pregnenoloneUse disordersCocaine cravingCue-induced cocaine cravingCue-induced anxietyWeeks of treatmentCue-induced cravingAutonomic arousalChronic cocaine usePreg groupBlood pressureDay groupRelapse riskHigher cocainePregnenolone levelsCue-provoked cravingSeparate daysAutonomic responsesCocaine useTreatment-seeking individualsCravingSteroid systems
2010
Cocaine
Beech R, Sinha R. Cocaine. 2010, 397-416. DOI: 10.1007/978-1-4419-0338-9_18.Peer-Reviewed Original ResearchCognitive behavior therapyBehavior therapyCocaine dependenceGeneral cognitive behavior therapyContingency managementRelapse prevention techniquesCompulsive drug seekingReward-related informationContingency management techniquesCocaine-taking behaviorConditions of challengeExecutive controlLong-term neuroadaptationsCocaine-related disordersDrug seekingCocaine useAdditional clinical attentionExtended abstinenceAnxiety disordersNeurobiological aspectsChronic cocaine useRegular cocaine useRelapse preventionPsychological symptomsNegative consequences