The pentapeptide QYNAD does not block voltage-gated sodium channels
Cummins T, Renganathan M, Herzog R, Dib-Hajj S, Waxman S, Stys P, Horn R. The pentapeptide QYNAD does not block voltage-gated sodium channels. Neurology 2003, 60: 1871-1872. PMID: 12796562, DOI: 10.1212/wnl.60.11.1871-a.Peer-Reviewed Original ResearchThe pentapeptide QYNAD does not block voltage-gated sodium channels
Cummins TR, Renganathan M, Stys PK, Herzog RI, Scarfo K, Horn R, Dib-Hajj SD, Waxman SG. The pentapeptide QYNAD does not block voltage-gated sodium channels. Neurology 2003, 60: 224-229. PMID: 12552035, DOI: 10.1212/01.wnl.0000042423.36650.bd.Peer-Reviewed Original ResearchConceptsVoltage-gated sodium channelsSodium channelsDifferent sodium channel subtypesSodium currentDorsal root ganglion neuronsInflammatory neurologic disordersMajor sodium channelPatch-clamp recordingsSodium channel subtypesSodium channel functionNodes of RanvierPentapeptide QYNADOptic nerveGanglion neuronsIntact neuronsNeurologic disordersQYNADChannel subtypesHuman CSFAbnormal myelinFiber tractsElevated levelsEndogenous pentapeptideMicro MChannel function