2017
Metabolic brain adaptations to recurrent hypoglycaemia may explain the link between type 1 diabetes mellitus and epilepsy and point towards future study and treatment options
Tricò D, Herzog RI. Metabolic brain adaptations to recurrent hypoglycaemia may explain the link between type 1 diabetes mellitus and epilepsy and point towards future study and treatment options. Diabetologia 2017, 60: 938-939. PMID: 28236055, PMCID: PMC5395303, DOI: 10.1007/s00125-017-4231-5.Peer-Reviewed Original Research
2013
Vaccination with Single Chain Antigen Receptors for Islet-Derived Peptides Presented on I-Ag7 Delays Diabetes in NOD Mice by Inducing Anergy in Self-Reactive T-Cells
Gurr W, Shaw M, Herzog RI, Li Y, Sherwin R. Vaccination with Single Chain Antigen Receptors for Islet-Derived Peptides Presented on I-Ag7 Delays Diabetes in NOD Mice by Inducing Anergy in Self-Reactive T-Cells. PLOS ONE 2013, 8: e69464. PMID: 23894487, PMCID: PMC3722102, DOI: 10.1371/journal.pone.0069464.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, Anti-IdiotypicClonal AnergyDiabetes Mellitus, Type 1FemaleMiceMice, Inbred NODMice, SCIDMice, TransgenicReceptors, Antigen, T-CellVaccinationConceptsSelf-reactive T cellsSingle chain receptorT cellsNOD miceB cellsReceptor repertoireSelf-reactive T cell clonesT cell receptor repertoireAnti-idiotypic vaccinationNormal NOD micePancreatic lymph nodesOnset of T1D.NOD-scid recipientsB cell receptor repertoireType 1 diabetesT cell clonesBDC2.5 TCRNOD recipientsProfound anergyLymph nodesSpecific autoantigensInducer cellsVaccination approachesMHC IVaccination