2020
Glutamate–Serine–Glycine Index: A Novel Potential Biomarker in Pediatric Non-Alcoholic Fatty Liver Disease
Leonetti S, Herzog RI, Caprio S, Santoro N, Tricò D. Glutamate–Serine–Glycine Index: A Novel Potential Biomarker in Pediatric Non-Alcoholic Fatty Liver Disease. Children 2020, 7: 270. PMID: 33291552, PMCID: PMC7761842, DOI: 10.3390/children7120270.Peer-Reviewed Original ResearchNon-alcoholic fatty liver diseaseAbdominal fat distributionFatty liver diseaseMagnetic resonance imagingGlycine indexLiver diseaseRisk factorsFat distributionPediatric non-alcoholic fatty liver diseasePotential biomarkersIntrahepatic fat accumulationIntrahepatic fat contentTraditional risk factorsRisk pediatric populationsBody mass indexLiver insulin resistanceTwofold higher prevalencePlasma amino acidsNovel potential biomarkersRace/ethnicityNAFLD prevalenceNAFLD patientsMass indexPediatric populationInsulin resistance
2017
A Branched-Chain Amino Acid-Related Metabolic Signature Characterizes Obese Adolescents with Non-Alcoholic Fatty Liver Disease
Goffredo M, Santoro N, Tricò D, Giannini C, D’Adamo E, Zhao H, Peng G, Yu X, Lam TT, Pierpont B, Caprio S, Herzog RI. A Branched-Chain Amino Acid-Related Metabolic Signature Characterizes Obese Adolescents with Non-Alcoholic Fatty Liver Disease. Nutrients 2017, 9: 642. PMID: 28640216, PMCID: PMC5537762, DOI: 10.3390/nu9070642.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseMagnetic resonance imagingBranched-chain amino acidsFatty liver diseaseHepatic fat contentObese adolescentsInsulin resistanceLiver diseaseTwo-step hyperinsulinemic-euglycemic clampOral glucose tolerance testSecond magnetic resonance imagingSubset of patientsGlucose tolerance testHyperinsulinemic-euglycemic clampHigher plasma levelsHepatic insulin sensitivityChain amino acidsPlasma levelsTolerance testInsulin sensitivityMetabolomic signaturePlasma metabolitesResonance imagingValine levelsLipid metabolism