Hypothermia for preventing chemotherapy-induced neuropathy – a pilot study on safety and tolerability in healthy controls
Bandla A, Sundar R, Liao L, Tan S, Lee S, Thakor N, Wilder-Smith E. Hypothermia for preventing chemotherapy-induced neuropathy – a pilot study on safety and tolerability in healthy controls. Acta Oncologica 2015, 55: 430-436. PMID: 26360921, DOI: 10.3109/0284186x.2015.1075664.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyHealthy human subjectsHealthy subjectsSevere chemotherapy-induced peripheral neuropathyDose-limiting side effectReduced nerve blood flowSeverity of chemotherapy-induced peripheral neuropathyLimb hypothermiaAdjuvant weekly paclitaxelChemotherapy-induced neuropathyNerve blood flowDuration of chemotherapyBreast cancer patientsSuccess of chemotherapyInfluence of hypothermiaEffects of hypothermiaWeekly paclitaxelSignificant adverse effectsPaclitaxel chemotherapyTreatment discontinuationTransient numbnessDose-relatedNeurotoxic drugsHuman subjectsCancer subjects