The chemo-brain effect in colorectal cancer patients.
Lee M, Chong W, Tan H, Chan G, Ho J, Sundar R, Chee C, Nasrallah F, Koo E, Yong W. The chemo-brain effect in colorectal cancer patients. Journal Of Clinical Oncology 2020, 38: e24095-e24095. DOI: 10.1200/jco.2020.38.15_suppl.e24095.Peer-Reviewed Original ResearchRapid Visual Information ProcessingQuality of lifePaired associate learningCambridge Neuropsychological Test Automated BatteryQLQ-C30 scoresMonths post-chemotherapyColorectal cancerRisk of poor recoveryMemory scoresHADS depression scoreQuality of Life QuestionnaireEORTC QLQ-C30 scoresPocket Smell TestHADS depressionLong-term cognitive impairmentDepression scoresPre-chemotherapyVisual information processingCorrelate of cognitive declinePost-chemotherapyColorectal cancer patientsNeuropsychological assessmentAssociative learningCognitive disturbancesBlood biomarker studiesConcomitant limb cryocompression and scalp cooling to reduce paclitaxel-induced neuropathy and alopecia.
Sundar R, Magarajah G, Ow S, Chan G, Choo J, Eng L, Wong A, Vijayan J, Hairom Z, Ang E, Paxman R, Wilder-Smith E, Thakor N, Lee S, Bandla A. Concomitant limb cryocompression and scalp cooling to reduce paclitaxel-induced neuropathy and alopecia. Journal Of Clinical Oncology 2020, 38: e24157-e24157. DOI: 10.1200/jco.2020.38.15_suppl.e24157.Peer-Reviewed Original ResearchChemotherapy-induced peripheral neuropathyPaclitaxel-induced neuropathyChemotherapy-induced alopeciaPost-chemotherapyScalp coolingAdverse effects of paclitaxelPreservation of nerve functionWeekly paclitaxel chemotherapyToxicity of paclitaxelEffects of paclitaxelReducing chemotherapy-induced alopeciaBreast cancer patientsLimb hypothermiaProof-of-concept studyPaclitaxel chemotherapyHypothermia trialTransient erythemaNo significant differencePatient toleranceRandomized studyNerve functionPre-chemotherapyPeripheral neuropathyChemotherapyCancer patients