2022
Phase Ib Dose-Finding Study of Varlitinib Combined with Weekly Paclitaxel With or Without Carboplatin ± Trastuzumab in Advanced Solid Tumors
Lee M, Wong A, Ow S, Sundar R, Tan D, Soo R, Chee C, Lim J, Yong W, Lim S, Goh B, Wang L, Lee S. Phase Ib Dose-Finding Study of Varlitinib Combined with Weekly Paclitaxel With or Without Carboplatin ± Trastuzumab in Advanced Solid Tumors. Targeted Oncology 2022, 17: 141-151. PMID: 35195837, PMCID: PMC8995271, DOI: 10.1007/s11523-022-00867-0.Peer-Reviewed Original ResearchConceptsHER2+ metastatic breast cancerDose-limiting toxicityMetastatic breast cancerBreast cancerSubcutaneous trastuzumabSolid tumorsConclusionsThe recommended phase II dosePharmacokinetic analysisRecommended phase II doseHER2+ breast cancerAdvanced solid tumorsPalliative systemic therapyMetastatic solid tumorsResultsThirty-seven patientsArea under the curveWeekly paclitaxelNeoadjuvant therapyStable diseaseFebrile neutropeniaPartial responseSystemic therapyMethodsEligible patientsEfficacy signalsElectrolyte disturbancesBiliary tract
2020
Neoadjuvant therapy in locally advanced colon cancer: a meta-analysis and systematic review
Cheong C, Nistala K, Ng C, Syn N, Chang H, Sundar R, Yang S, Chong C. Neoadjuvant therapy in locally advanced colon cancer: a meta-analysis and systematic review. Journal Of Gastrointestinal Oncology 2020, 11: 847-857. PMID: 33209481, PMCID: PMC7657836, DOI: 10.21037/jgo-20-220.Peer-Reviewed Original ResearchLocally advanced colon cancerAdvanced colon cancerR0 resection rateDisease-free survivalNeoadjuvant chemotherapyColon cancerNeoadjuvant therapyRandomized controlled trialsOverall survivalResection rateAdjuvant chemotherapyChina Knowledge Resource Integrated DatabaseSurvival benefit of neoadjuvant chemotherapyBenefit of neoadjuvant chemotherapyRisk of peri-operative complicationsObservational studyObservational study of patientsAdverse effects of chemotherapyPeri-operative complicationsPotential survival benefitMeta-analysisEffects of chemotherapyStudy of patientsFOxTROT trialUpfront operation