Profiling of gastric cancer cell-surface markers to achieve tumour–normal discrimination
Toh J, Hoppe M, Thakur T, Yang H, Tan K, Pang B, Ho S, Roy R, Ho K, Yeoh K, Tan P, Sundar R, Jeyasekharan A. Profiling of gastric cancer cell-surface markers to achieve tumour–normal discrimination. BMJ Open Gastroenterology 2020, 7: e000452. PMID: 32816956, PMCID: PMC7437876, DOI: 10.1136/bmjgast-2020-000452.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAntigens, CDAntigens, Tumor-Associated, CarbohydrateCA-19-9 AntigenCarcinoembryonic AntigenCell Adhesion MoleculesClaudin-4ClaudinsEpithelial Cell Adhesion MoleculeEvaluation Studies as TopicExome SequencingGenomicsGPI-Linked ProteinsHumansImmunohistochemistryMembrane ProteinsROC CurveSensitivity and SpecificitySingaporeStomach NeoplasmsUp-RegulationConceptsWhole-transcriptome sequencingCell surface markersMultispectral immunohistochemistryPutative cell surface proteinGastric cancerNormal tissuesMatched normal samplesCA72-4Cell surface proteinsTumor tissuesLive imaging approachesAnalysis of cell surface markersMolecular profiling of cancersHighest diagnostic validityIdentification of tumor tissueTranscriptome sequencingCancer Genome AtlasProfile of cancerProtein transcriptsCancer cell surface markersCA19-9Genome AtlasDifferentiated tumorsTissue microarrayTCGA data