2020
Activation of sphingosine 1-phosphate receptor 2 attenuates chemotherapy-induced neuropathy
Wang W, Xiang P, Chew W, Torta F, Bandla A, Lopez V, Seow W, Lam B, Chang J, Wong P, Chayaburakul K, Ong W, Wenk M, Sundar R, Herr D. Activation of sphingosine 1-phosphate receptor 2 attenuates chemotherapy-induced neuropathy. Journal Of Biological Chemistry 2020, 295: 1143-1152. DOI: 10.1016/s0021-9258(17)49922-4.Peer-Reviewed Original ResearchChemotherapy-induced neuropathyRat model of cisplatin-induced neuropathyManagement of chemotherapy-induced neuropathyTreatment of chemotherapy-induced neuropathyS1P speciesEffects of platinum-based drugsCisplatin-induced neuropathyPlasma S1P levelsDorsal root gangliaHuman cancer patientsActivating stress-response proteinsPlatinum-based drugsSphingosine 1-phosphateReduced allodyniaS1P1 signalingOxaliplatin treatmentPharmacodynamic analysisPeripheral neuropathyRat modelCancer patientsLipid-based signaling moleculesS1P concentrationsS1P levelsCYM-5478Platinum-based therapeutics
2019
Activation of sphingosine 1-phosphate receptor 2 attenuates chemotherapy-induced neuropathy
Wang W, Xiang P, Chew W, Torta F, Bandla A, Lopez V, Seow W, Lam B, Chang J, Wong P, Chayaburakul K, Ong W, Wenk M, Sundar R, Herr D. Activation of sphingosine 1-phosphate receptor 2 attenuates chemotherapy-induced neuropathy. Journal Of Biological Chemistry 2019, 295: 1143-1152. PMID: 31882542, PMCID: PMC6983853, DOI: 10.1074/jbc.ra119.011699.Peer-Reviewed Original ResearchConceptsChemotherapy-induced neuropathyRat model of cisplatin-induced neuropathyManagement of chemotherapy-induced neuropathyTreatment of chemotherapy-induced neuropathyS1P speciesEffects of platinum-based drugsCisplatin-induced neuropathyPlasma S1P levelsDorsal root gangliaS1P<sub>1-5</sub>Human cancer patientsActivating stress-response proteinsPlatinum-based drugsReduced allodyniaSphingosine 1-phosphateOxaliplatin treatmentPharmacodynamic analysisPeripheral neuropathyRat modelS1PCancer patientsLipid-based signaling moleculesS1P concentrationsS1P levelsCYM-5478
2015
Hypothermia for preventing chemotherapy-induced neuropathy – a pilot study on safety and tolerability in healthy controls
Bandla A, Sundar R, Liao L, Tan S, Lee S, Thakor N, Wilder-Smith E. Hypothermia for preventing chemotherapy-induced neuropathy – a pilot study on safety and tolerability in healthy controls. Acta Oncologica 2015, 55: 430-436. PMID: 26360921, DOI: 10.3109/0284186x.2015.1075664.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyHealthy human subjectsHealthy subjectsSevere chemotherapy-induced peripheral neuropathyDose-limiting side effectReduced nerve blood flowSeverity of chemotherapy-induced peripheral neuropathyLimb hypothermiaAdjuvant weekly paclitaxelChemotherapy-induced neuropathyNerve blood flowDuration of chemotherapyBreast cancer patientsSuccess of chemotherapyInfluence of hypothermiaEffects of hypothermiaWeekly paclitaxelSignificant adverse effectsPaclitaxel chemotherapyTreatment discontinuationTransient numbnessDose-relatedNeurotoxic drugsHuman subjectsCancer subjects