DNA epigenetic signature predictive of benefit from neoadjuvant chemotherapy in oesophageal adenocarcinoma: results from the MRC OE02 trial
Sundar R, Ng A, Zouridis H, Padmanabhan N, Sheng T, Zhang S, Lee M, Ooi W, Qamra A, Inam I, Hewitt L, So J, Koh V, Nankivell M, Langley R, Allum W, Cunningham D, Rozen S, Yong W, Grabsch H, Tan P. DNA epigenetic signature predictive of benefit from neoadjuvant chemotherapy in oesophageal adenocarcinoma: results from the MRC OE02 trial. European Journal Of Cancer 2019, 123: 48-57. PMID: 31655359, DOI: 10.1016/j.ejca.2019.09.016.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsCisplatinDNA MethylationEpigenesis, GeneticEsophageal NeoplasmsFemaleFluorouracilHumansMaleMiddle AgedNeoadjuvant TherapyNeoplasm GradingNeoplasm StagingPrognosisProportional Hazards ModelsRandomized Controlled Trials as TopicSurvival RateConceptsCS armNeoadjuvant chemotherapyOverall survivalOesophageal adenocarcinomaDNA methylation signaturesHistological subtypes of oesophageal cancerOesophageal cancerIndependent cohortPredictive of chemotherapy benefitSubtypes of oesophageal cancerIndependent cohort of patientsS armCox proportional hazards analysisResectable oesophageal cancerCohort of patientsPredictive of benefitMethylation signaturesDNA methylationPredictive of survivalProportional hazards analysisChemotherapy benefitHistological subtypesMetagene signatureRandomised patientsDNA methylation statusDNA methylation signature predictive of benefit from neoadjuvant chemotherapy in esophageal adenocarcinoma: Results from the MRC OEO2 phase III trial.
Sundar R, Ng A, Zouridis H, Sheng T, Zhang S, Lee M, Padmanabhan N, Ooi W, Qamra A, Nankivell M, Langley R, Allum W, Cunningham D, Grabsch H, Tan P. DNA methylation signature predictive of benefit from neoadjuvant chemotherapy in esophageal adenocarcinoma: Results from the MRC OEO2 phase III trial. Journal Of Clinical Oncology 2019, 37: 43-43. DOI: 10.1200/jco.2019.37.4_suppl.43.Peer-Reviewed Original ResearchDNA methylationCpG sitesMethylation signaturesChemotherapy benefitNeoadjuvant chemotherapyPoor riskGood riskMethylation statusDNA methylation of genesIndependent predictor of survivalDNA methylation signaturesPredictive marker of survivalIllumina GoldenGate platformMethylation of genesCycles of cisplatinCox proportional hazards analysisResectable esophageal carcinomaMarker of survivalPredictive of benefitPredictors of survivalProportional hazards analysisGoldenGate platformSite signatureEpigenetic signaturesSurgery arm