2022
Obstructive sleep apnea and the incidence and mortality of gastrointestinal cancers: a systematic review and meta-analysis of 5,120,837 participants
Teo Y, Tan B, Tan N, Yap D, Chai Y, Teo Y, Sia C, Sundar R, Tan E, See A, Toh S. Obstructive sleep apnea and the incidence and mortality of gastrointestinal cancers: a systematic review and meta-analysis of 5,120,837 participants. Journal Of Gastrointestinal Oncology 2022, 0: 0-0. PMID: 36636076, PMCID: PMC9830329, DOI: 10.21037/jgo-22-153.Peer-Reviewed Original ResearchObstructive sleep apneaAssociation of obstructive sleep apneaSleep apneaGastrointestinal cancerCancer incidenceColorectal cancerMeta-analysisPancreatic cancerFollow-upObstructive sleep apnea screeningYears of median follow-upColorectal cancer screening guidelinesLong-term follow-upIncreased risk of colorectal cancerIncreased incidence of colorectal cancerRisk of colorectal cancerIncidence of colorectal cancerMedian follow-upPancreatic cancer incidenceCancer screening guidelinesSleep apnea screeningIncidence of gastrointestinal cancerMortality of gastrointestinal cancersSystematic reviewHigh-risk individuals
2020
Metformin and colorectal cancer: a systematic review, meta-analysis and meta-regression
Ng C, Jiang A, Toh E, Ng C, Ong Z, Peng S, Tham H, Sundar R, Chong C, Khoo C. Metformin and colorectal cancer: a systematic review, meta-analysis and meta-regression. International Journal Of Colorectal Disease 2020, 35: 1501-1512. PMID: 32592092, DOI: 10.1007/s00384-020-03676-x.Peer-Reviewed Original ResearchConceptsColorectal adenomasCancer incidenceImprove colorectal cancer outcomesNon-metformin usersColorectal cancerIncidence of colorectal adenomasMeta-analysisMetformin usersIncidence of colorectal cancerHazard ratioRisk ratioReducing colorectal adenomasColorectal cancer outcomesCRC-specific survivalCancer survival outcomesEffect of metformin useMetformin useSurvival outcomesAdvanced adenomasDiet-only treatmentDerSimonian and LairdCancer outcomesOverall survivalMethodsA database searchConclusionThis meta-analysis