2024
Placental Vascular Anastamoses and Associated Pathologies in Dichorionic Twin Gestations.
Dave E, Ozan Bahtiyar M, Campbell W, Morotti R, Kohari K. Placental Vascular Anastamoses and Associated Pathologies in Dichorionic Twin Gestations. Twin Research And Human Genetics 2024, 1-5. PMID: 39508257, DOI: 10.1017/thg.2024.35.Peer-Reviewed Original ResearchTwin-to-twin transfusion syndromeTwin anemia-polycythemia sequenceDichorionic twin gestationsVascular anastamosesTwin gestationsDichorionic twin pregnanciesTwin transfusion syndromePlacental vascular anastomosesDichorionic gestationsMonochorionic pregnanciesPrenatal surveillanceTransfusion syndromeTwin pregnanciesGestationMitigate morbidityVascular anastomosisAssociated pathologyPregnancyAnastamosesPathologyDichorionicityMorbidityPathophysiologySyndromeExpanding the spectrum of progressive familial intrahepatic cholestasis: A report of 3 cases
Jiao J, Morotti R, Shafizadeh N, Jain D. Expanding the spectrum of progressive familial intrahepatic cholestasis: A report of 3 cases. American Journal Of Clinical Pathology 2024, aqae123. PMID: 39333837, DOI: 10.1093/ajcp/aqae123.Peer-Reviewed Original ResearchProgressive familial intrahepatic cholestasisATP-binding cassette subfamily B member 4Whole-exome sequencingFamilial intrahepatic cholestasisIntrahepatic cholestasisDiagnostic challengeGroup of autosomal recessive disordersAbnormal liver function testsHomozygous splice site variantDrug-induced liver injuryHeterozygous frameshift mutationHeterozygous missense mutationLiver function testsAged 2 monthsAutosomal recessive disorderSplice site variantHistory of alcoholismABCB4 mutationsPediatric ageLiver biopsyClinical historyRecessive disorderLiver injuryMolecular testingHeterogeneous presentationWhen lungs and weights tell different stories
Godse S, Brumer E, Kizilirmak T, Canapari C, Silva C, Morotti R, Jiang Y, Jeffries L, Chen L, Panacherry S. When lungs and weights tell different stories. Pediatric Pulmonology 2024, 59: 1047-1059. PMID: 38353400, DOI: 10.1002/ppul.26832.Peer-Reviewed Original ResearchMolecular Genetics Augment Cytopathologic Evaluation and Surgical Planning of Pediatric Thyroid Nodules
Spaulding S, Maayah M, Dinauer C, Prasad M, Darbinyan A, Morotti R, Christison-Lagay E. Molecular Genetics Augment Cytopathologic Evaluation and Surgical Planning of Pediatric Thyroid Nodules. Journal Of Pediatric Surgery 2024, 59: 975-980. PMID: 38246817, DOI: 10.1016/j.jpedsurg.2024.01.001.Peer-Reviewed Original ResearchFine-needle aspiration biopsyPediatric thyroid nodulesMolecular genetic testingBethesda IV nodulesPrediction of malignancyDICER1 mutationsThyroid nodulesGenetic testingNRAS mutationsMethods Retrospective chart reviewRetrospective chart reviewTime of surgeryBRAF V600E testingMutations/fusionsBethesda III nodulesChart reviewSurgical resectionFinal histopathologyThyroid resectionPediatric dataHistologic classificationSurgical specimensBRAF mutationsAspiration biopsyCytopathologic evaluation
2022
Isolated Terminal Ileitis in Children
Alper A, Bennett A, Rottmann D, Morotti R, Escalera S, Phatak U, Pashankar D. Isolated Terminal Ileitis in Children. Journal Of Pediatric Gastroenterology And Nutrition 2022, 76: 338-342. PMID: 36729703, DOI: 10.1097/mpg.0000000000003679.Peer-Reviewed Original ResearchConceptsCrohn's diseaseTerminal ileitisAbnormal C-reactive protein levelsC-reactive protein levelsBowel wall thickeningLong-term outcomesRadiological evidenceRadiological featuresSevere inflammationPediatric literatureHigh prevalenceIleitisWall thickeningProtein levelsChildrenPrevalenceAdultsColonoscopyInflammationEndoscopicHistologicDiseaseMonths
2020
Motility Disorders of the Gastrointestinal Tract
Morotti R, Jain D. Motility Disorders of the Gastrointestinal Tract. Practical Anatomic Pathology 2020, 313-337. DOI: 10.1007/978-3-030-51268-2_13.Peer-Reviewed Original ResearchMotility disordersGastrointestinal tractRole of immunohistochemistryVisceral myopathyVisceral neuropathyClinical correlatesHirschsprung's diseaseHistologic characteristicsCommon disorderAdverse effectsDisordersHistochemical stainsMotility functionTractNeuropathyMedicationsImmunohistochemistryWorkupMyopathyDiseaseDiagnosisPediatric unilobar resection in primary ciliary dyskinesia.
Sendon C, Cowles R, Worhunsky D, Hodson D, Morotti R, Bazzy-Asaad A, Esquibies A. Pediatric unilobar resection in primary ciliary dyskinesia. Minerva Pediatrica 2020, 74: 593-599. PMID: 32731729, DOI: 10.23736/s2724-5276.20.05802-8.Peer-Reviewed Original ResearchConceptsPrimary ciliary dyskinesiaSevere lung diseasePulmonary functionLung diseaseCiliary dyskinesiaAggressive medical managementSelective surgical removalQuality of lifeProgressive bronchiectasisUnilobar diseaseProphylactic antibioticsLung resectionAggressive administrationAirway clearanceMedical managementChronic bronchiectasisTherapy optionsLocalized bronchiectasisSurgical removalChronic infectionBronchiectasisRare caseAlternative treatmentNutritional statusNecrotic areas
2018
29 Intrahepatic Cholestasis
Saxena R, Ghabril M, Morotti R, Saxena R. 29 Intrahepatic Cholestasis. 2018, 445-464. DOI: 10.1016/b978-0-323-42873-6.00029-9.Peer-Reviewed Original Research
2017
OR51 Correlation of class II antibody development with acute cellular rejection and fibrosis in pediatric liver transplantation
Bow L, Ekong U, Morotti R, Antala S, Emre S. OR51 Correlation of class II antibody development with acute cellular rejection and fibrosis in pediatric liver transplantation. Human Immunology 2017, 78: 47. DOI: 10.1016/j.humimm.2017.06.057.Peer-Reviewed Original ResearchAcute cellular rejectionClass II DSAPediatric liver transplantationLiver transplantationCellular rejectionHLA antibodiesFibrosis scoreDe novo HLA antibodiesNovo HLA antibodiesSided p valueDiagnosis of antibodyWilcoxon rank sumContinuous variablesGraft dysfunctionMean fibrosisSinusoidal fibrosisGraft functionPost transplantRejection gradeAvailable biopsiesLiver dysfunctionPatient characteristicsAntibody levelsDSA developmentSpecificity of antibodies
2016
CONGENITAL CYSTIC LUNG LESIONS: EVOLUTION FROM IN-UTERO TO PATHOLOGY DIAGNOSIS - A MULTIDISCIPLINARY APPROACH
Hardee S, Tuzovic L, Silva C, Cowles R, Copel J, Morotti R. CONGENITAL CYSTIC LUNG LESIONS: EVOLUTION FROM IN-UTERO TO PATHOLOGY DIAGNOSIS - A MULTIDISCIPLINARY APPROACH. Pediatric And Developmental Pathology 2016 DOI: 10.2350/16-05-1815-oa.1.Peer-Reviewed Original ResearchCongenital cystic lung lesionsCongenital pulmonary airway malformationBronchopulmonary sequestrationPrenatal ultrasoundSingle tertiary care centerCystic lung lesionsPulmonary airway malformationTertiary care centerFinal pathologic diagnosisCorrelate imagingCPAM lesionsAirway malformationExcellent prognosisPathological findingsPostnatal imagingRetrospective reviewPathology databaseSurgical interventionRare pathologyBronchial atresiaLung lesionsPathologic diagnosisPrenatal coursePathology examinationCare centerCongenital Extrahepatic Portosystemic Shunt (Abernethy Malformation Type Ib) with Associated Hepatocellular Carcinoma: Case report and Literature Review
Benedict M, Rodriguez-Davalos M, Emre S, Walther Z, Morotti R. Congenital Extrahepatic Portosystemic Shunt (Abernethy Malformation Type Ib) with Associated Hepatocellular Carcinoma: Case report and Literature Review. Pediatric And Developmental Pathology 2016 DOI: 10.2350/16-01-1761-cr.1.Peer-Reviewed Case Reports and Technical NotesAbernethy malformationCongenital portosystemic shuntsHepatocellular carcinomaPortosystemic shuntPortal veinVena cavaCongenital absenceCongenital extrahepatic portosystemic shuntAssociated Hepatocellular CarcinomaSplanchnic venous systemNodular regenerative hyperplasiaExtrahepatic portosystemic shuntMonth old maleSmall hepatocellular carcinomaFocal nodular hyperplasiaRegenerative hyperplasiaClinical manifestationsIntrahepatic shuntsLiver adenomasCase reportImmunohistochemical characteristicsPortal bloodTypical presentationVenous systemNodular hyperplasiaAcquired seminal vesicle cyst in a teenager with a urethral stricture of unknown etiology
Farrelly J, Cleary M, Weiss R, Morotti R, Stitelman D. Acquired seminal vesicle cyst in a teenager with a urethral stricture of unknown etiology. Journal Of Pediatric Surgery Case Reports 2016, 7: 8-12. DOI: 10.1016/j.epsc.2016.01.002.Peer-Reviewed Original ResearchSeminal vesicle cystUrethral strictureUpper urinary tract anatomyUpper urinary tract anomaliesLower urinary tract signsUrinary tract anatomyUrinary tract anomaliesUrinary tract signsUrethral inflammationTract anomaliesTract signsPediatric populationBulbar urethraRare diagnosisUnknown etiologyUrethral pathologyComplete resolutionYounger ageTract anatomyUnique caseCystsStrictureInflammationPatientsUrethraTu1692 Decreased Prevalence and Severity of NAFLD in African American Children in NYC: An Autopsy Study
Fernandes D, Pantangi V, Duong J, Salomao M, Iuga A, Morotti R, Gill J, Lefkowitch J, Lavine J, Mencin A. Tu1692 Decreased Prevalence and Severity of NAFLD in African American Children in NYC: An Autopsy Study. Gastroenterology 2016, 150: s926-s927. DOI: 10.1016/s0016-5085(16)33141-9.Peer-Reviewed Original Research
2014
Su1775 Duodenitis in Children Undergoing Upper Endoscopy
Alper A, Rojas-Velasquez D, Morotti R, Escalera S, Pashankar D, Hardee S. Su1775 Duodenitis in Children Undergoing Upper Endoscopy. Gastrointestinal Endoscopy 2014, 79: ab399. DOI: 10.1016/j.gie.2014.02.519.Peer-Reviewed Original Research
2013
Su1859 Eosinophilic Gastritis in Children: Clinicopathological Correlation, Disease Course, and Response to Therapy
Ko H, Morotti R, Yershov O, Chehade M. Su1859 Eosinophilic Gastritis in Children: Clinicopathological Correlation, Disease Course, and Response to Therapy. Gastroenterology 2013, 144: s-493. DOI: 10.1016/s0016-5085(13)61824-7.Peer-Reviewed Original ResearchPediatric Obesity and the Liver
Hardee S, Morotti R. Pediatric Obesity and the Liver. Academic Forensic Pathology 2013, 3: 28-33. DOI: 10.23907/2013.005.Peer-Reviewed Original ResearchNonalcoholic fatty liver diseasePediatric nonalcoholic steatohepatitisFatty liver diseaseNonalcoholic steatohepatitisLiver diseaseAdult nonalcoholic steatohepatitisVariable fibrosisPediatric obesityPediatric populationMacrovesicular steatosisBallooning degenerationPediatric nonalcoholic fatty liver diseaseDifficult diagnostic entityPortal tract inflammationPediatric liver diseaseNoninvasive screening toolLobular inflammationSimple steatosisObese childrenPerisinusoidal fibrosisCardiovascular diseaseCommon causePrevalence ratesObesity epidemicObesity rates
2012
Toddler Fatalities: The Terrible Twos
Gill J, Vincent G, Morotti R. Toddler Fatalities: The Terrible Twos. Academic Forensic Pathology 2012, 2: 332-337. DOI: 10.23907/2012.051.Peer-Reviewed Original ResearchChief Medical ExaminerDifferential diagnosisMedical examinersNew York City OfficeDeath certificate dataCause of deathMedical examiner/coronerYears of ageThorough histologic examinationAsphyxial mechanismsSeizure disorderTherapeutic complicationsUndetermined causeChildhood deathsHistologic examinationCertificate dataToxin ingestionAccidental injuryUndetermined deathsDeathDiagnosisCoronersExaminersYear periodAgeDietary Therapy and Topical Corticosteroids Can Reverse Esophageal Fibrosis in Patients with Eosinophilic Esophagitis
Lieberman J, Morotti R, Yershov O, Chehade M. Dietary Therapy and Topical Corticosteroids Can Reverse Esophageal Fibrosis in Patients with Eosinophilic Esophagitis. Journal Of Allergy And Clinical Immunology 2012, 129: ab246. DOI: 10.1016/j.jaci.2011.12.055.Peer-Reviewed Original Research
2011
Progressive Familial Intrahepatic Cholestasis (PFIC) Type 1, 2, and 3: A Review of the Liver Pathology Findings
Morotti R, Suchy F, Magid M. Progressive Familial Intrahepatic Cholestasis (PFIC) Type 1, 2, and 3: A Review of the Liver Pathology Findings. Seminars In Liver Disease 2011, 31: 003-010. PMID: 21344347, DOI: 10.1055/s-0031-1272831.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 11ATP-Binding Cassette TransportersCholestasis, IntrahepaticDisease ProgressionGenetic Predisposition to DiseaseHeredityHumansLiverPhenotypePrognosisTerminology as TopicConceptsProgressive familial intrahepatic cholestasis type 1Intrahepatic cholestatic diseasesLiver pathology findingsCharacteristic pathologic featuresAutosomal recessive hereditary diseaseBile acid formationRecessive hereditary diseaseLiver histologyPathologic featuresHepatocellular originPathology findingsCholestatic diseaseDisease progressionFIC1 deficiencyMDR3 deficiencyBSEP deficiencyType 1DiseaseHereditary diseaseFirst descriptionDeficiencySpecific genotypesMolecular studiesCholestasisComplications
2009
890 Reversibility of Esophageal Fibrosis in Response to Various Therapies in Children with Eosinophilic Esophagitis
Chehade M, Yershov O, Mayer L, Magid M, Morotti R, Sampson H. 890 Reversibility of Esophageal Fibrosis in Response to Various Therapies in Children with Eosinophilic Esophagitis. Gastroenterology 2009, 136: a-138. DOI: 10.1016/s0016-5085(09)60619-3.Peer-Reviewed Original Research