Exhaustive acute exercise-induced ER stress is attenuated in IL-6-knockout mice
Pinto A, da Rocha A, Kohama E, Gaspar R, Simabuco F, Frantz F, de Moura L, Pauli J, Cintra D, Ropelle E, de Freitas E, da Silva A. Exhaustive acute exercise-induced ER stress is attenuated in IL-6-knockout mice. Journal Of Endocrinology 2019, 240: 181-193. PMID: 30400033, DOI: 10.1530/joe-18-0404.Peer-Reviewed Original ResearchConceptsIL-6 knockout miceExtensor digitorium longusPhysical exercise protocolAcute exercise protocolER stress proteinsExercise protocolIL-6WT groupIL-6 KO groupSerum levelsKO groupExercise-induced IL-6IL-6 concentrationsWild-type miceIntense physical exerciseER stressEndoplasmic reticulum stressStress proteinsIL-10Interleukin-6Knockout micePhysical exerciseSoleusHomeostatic functionsMiceLifelong exercise practice and immunosenescence: Master athletes cytokine response to acute exercise
Minuzzi L, Chupel M, Rama L, Rosado F, Muñoz V, Gaspar R, Kuga G, Furtado G, Pauli J, Teixeira A. Lifelong exercise practice and immunosenescence: Master athletes cytokine response to acute exercise. Cytokine 2019, 115: 1-7. PMID: 30616033, DOI: 10.1016/j.cyto.2018.12.006.Peer-Reviewed Original ResearchConceptsMiddle-aged groupAnti-inflammatory cytokinesMaster athletesAcute exerciseIL-1βIL-4IL-10 levelsAcute exercise effectsMiddle age groupIL-17IL-10IL-1raMaximal incremental testIL-6IL-8Mean VOExercise effectsBlood samplesCycle ergometerExercise practiceAthlete groupCytokinesYounger groupYoung adultsIncremental test