Overexpression of Mitogen-activated protein kinase phosphatase-3 (MKP-3) reduces FoxO1 phosphorylation in mice hypothalamus
de Almeida Rodrigues B, Kuga G, Muñoz V, Gaspar R, Tavares M, Botezelli J, da Silva A, Cintra D, de Moura L, Simabuco F, Ropelle E, Pauli J. Overexpression of Mitogen-activated protein kinase phosphatase-3 (MKP-3) reduces FoxO1 phosphorylation in mice hypothalamus. Neuroscience Letters 2017, 659: 14-17. PMID: 28866049, DOI: 10.1016/j.neulet.2017.08.067.Peer-Reviewed Original ResearchConceptsFoxO1 phosphorylationMKP-3 overexpressionDephosphorylation of FOXO1Potential therapeutic targetInjection of adenovirusOrexigenic neuropeptidesHypothalamic disorderHypothalamic third ventricleSwiss miceInsulin intracellularHypothalamic activationThird ventricleTherapeutic targetFoxO1 dephosphorylationAkt phosphorylationInsulin signalingImportant transcription factorDUSP6 geneHypothalamusSignificant reductionFOXO1MiceInsulin stimulationPresent studyInsulin signal